Application of optimal experimental design concept to improve the estimation of model parameters in microbial thermal inactivation kinetics

MM Gil, FA Miller, CLM Silva, TRS Brandão - Journal of Food Engineering, 2014 - Elsevier
The estimation of model parameters with high precision is of major importance in
mathematical predictions. If a mathematical model is properly chosen and if the primary …

Introducing optimal experimental design in predictive modeling: A motivating example

KJ Versyck, K Bernaerts, AH Geeraerd… - International Journal of …, 1999 - Elsevier
Predictive microbiology emerges more and more as a rational quantitative framework for
predicting and understanding microbial evolution in food products. During the mathematical …

On the design of optimal dynamic experiments for parameter estimation of a Ratkowsky-type growth kinetics at suboptimal temperatures

K Bernaerts, KJ Versyck, JF Van Impe - International journal of food …, 2000 - Elsevier
It is generally known that accurate model building, ie, proper model structure selection and
reliable parameter estimation, constitutes an essential matter in the field of predictive …

Mathematical models for prediction of temperature effects on kinetic parameters of microorganisms' inactivation: Tools for model comparison and adequacy in data …

MM Gil, FA Miller, TRS Brandão, CLM Silva - Food and Bioprocess …, 2017 - Springer
Microbial inactivation often follows a sigmoidal kinetic behaviour, with an initial lag phase,
followed by a maximum inactivation rate period and tending to a final asymptotic value …

Guidelines for the design of (optimal) isothermal inactivation experiments

JL Peñalver-Soto, A Garre, A Esnoz… - Food Research …, 2019 - Elsevier
Kinetic models are nowadays a basic tool to ensure food safety. Most models used in
predictive microbiology have model parameters, whose precision is crucial to provide …

Optimal characterization of thermal microbial inactivation simulating non-isothermal processes

A Garre, G González-Tejedor, JL Peñalver-Soto… - Food Research …, 2018 - Elsevier
In this paper, optimal experimental design is applied for the characterization of the microbial
inactivation of Listeria monocytogenes under non-isothermal conditions, modelled by the …

Computing optimal dynamic experiments for model calibration in predictive microbiology

E BALSA‐CANTO, AA Alonso… - Journal of Food Process …, 2008 - Wiley Online Library
The potential of mathematical models describing the microbial behavior during food
processing and storage largely depends on their predictive capabilities and, in this concern …

An optimization algorithm for estimation of microbial survival parameters during thermal processing

G Chen, OH Campanella - International Journal of Food Microbiology, 2012 - Elsevier
Isothermal microbial survival curves are usually described by either linear or nonlinear time-
dependent models, from which non-isothermal survival curves can be generated if the …

On the use of the Gompertz model to predict microbial thermal inactivation under isothermal and non-isothermal conditions

MM Gil, FA Miller, TRS Brandao, CLM Silva - Food Engineering Reviews, 2011 - Springer
Food processes should be designed to provide an adequate margin of safety against
microbiological risk of food poisoning and food spoilage throughout shelf life. In this field, the …

[HTML][HTML] Incorporating strain variability in the design of heat treatments: A stochastic approach and a kinetic approach

MH Zwietering, A Garre, HMW den Besten - Food Research International, 2021 - Elsevier
For the design of thermal processes, the decimal reduction times (D-values) of target
organisms can be used. However, many factors influence the D-value, like inherent …