The aim of our study was to assess the cytokine profile of sickle cell disease (SCD) patients
in steady state and in vaso‐occlusive crisis (VOC). VOC has a complex nature, involving …

Background Effective treatment and management of sickle cell disease (SCD) has been a
challenge in Africa over the years. Hematological parameters are very useful profiles in the …

Sickle cell disease (SCD) is characterized by chronic hemolysis, frequent infections, and
recurrent occlusions of microcirculation, which cause painful crises and result in chronic …

Sickle cell disease (SCD) is characterized by recurrent vaso-occlusive crisis (VOC). Patients
with SCD have impaired immunity and are thus predispose to infections. The vast majority of …

The pathogenesis of sickle vaso-occlusive crisis (VOC) in sickle cell disease (SCD) patients
involves the accumulation of rigid sickle cells and the stimulation of an ongoing inflammatory …

Sickle cell anemia (SCA) pathophysiology is characterized by the activation of sickle red
blood cells, reticulocytes, leukocytes, platelets, and endothelial cells, and with the …

Sickle Cell Anemia (SCA) is the most common genetic disorder around the world. The
mutation in the β-globin gene is responsible for a higher hemolysis rate, with further …

The hyperhemolysis paradigm that describes overlapping “hyperhemolytic-endothelial
dysfunction” and “high hemoglobin-hyperviscous” subphenotypes of sickle cell disease …

Background: Sickle cell anaemia (SCA) is a major cause of morbidity and mortality in Africa
where there is no readily available effective treatment. This study was designed to determine …

Vasoocclusion leads to pain, chronic organ damage, and a decreased life expectancy in
patients with sickle cell disease. Therapeutic options for sickle cell disease have usually …