Role of A2B adenosine receptor-dependent adenosine signaling in multi-walled carbon nanotube-triggered lung fibrosis in mice

B Liu, Q Bing, S Li, B Han, J Lu, R Baiyun… - Journal of …, 2019 - Springer
Background Multi-walled carbon nanotube (MWCNT)-induced lung fibrosis leads to health
concerns in human. However, the mechanisms underlying fibrosis pathogenesis remains …

Multiwall carbon nanotubes directly promote fibroblast–myofibroblast and epithelial–mesenchymal transitions through the activation of the TGF‐β/Smad signaling …

P Wang, Y Wang, X Nie, C Braïni, R Bai, C Chen - Small, 2015 - Wiley Online Library
A number of studies have demonstrated that MWCNTs induce granuloma formation and
fibrotic responses in vivo, and it has been recently reported that MWCNT‐induced …

Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-β-mediated Akt/GSK-3β/SNAIL-1 …

M Polimeni, GR Gulino, E Gazzano, J Kopecka… - Particle and fibre …, 2015 - Springer
Background Multi-walled carbon nanotubes (MWCNT) are currently under intense
toxicological investigation due to concern on their potential health effects. Current in vitro …

Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF‐β/Smad signaling pathway

P Wang, X Nie, Y Wang, Y Li, C Ge, L Zhang, L Wang… - Small, 2013 - Wiley Online Library
Multiwall carbon nanotubes (MWCNTs) have been widely used in many disciplines due to
their unique physical and chemical properties, but have also raised great concerns about …

Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-κB signaling, and promoting fibroblast-to …

X He, SH Young, D Schwegler-Berry… - Chemical research in …, 2011 - ACS Publications
Carbon nanotubes (CNTs) are novel materials with unique electronic and mechanical
properties. The extremely small size, fiberlike shape, large surface area, and unique surface …

Identification of TGF-β receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis

A Mishra, TA Stueckle, RR Mercer… - … of Physiology-Lung …, 2015 - journals.physiology.org
Carbon nanotubes (CNTs) induce rapid interstitial lung fibrosis, but the underlying
mechanisms are unclear. Previous studies indicated that the ability of CNTs to penetrate …

[HTML][HTML] C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment

J Zhu, X Zhang, L Li, H Yang, H Liu, D Wu, Z Liu… - Ecotoxicology and …, 2025 - Elsevier
A mounting number of studies have been documenting strong pro-inflammatory and pro-
fibrotic effects of carbon nanotube (CNT). However, the molecular mechanisms of single …

Effect of fiber length on carbon nanotube-induced fibrogenesis

A Manke, S Luanpitpong, C Dong, L Wang… - International journal of …, 2014 - mdpi.com
Given their extremely small size and light weight, carbon nanotubes (CNTs) can be readily
inhaled by human lungs resulting in increased rates of pulmonary disorders, particularly …

Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts

S Hussain, S Sangtian, SM Anderson… - Particle and fibre …, 2014 - Springer
Background In vivo studies have demonstrated the ability of multi-walled carbon nanotubes
(MWCNT) to induce airway remodeling, a key feature of chronic respiratory diseases like …

Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung

X Wang, T Xia, S Addo Ntim, Z Ji, S Lin, H Meng… - ACS …, 2011 - ACS Publications
We developed a dispersal method for multiwalled carbon nanotubes (MWCNTs) that allows
quantitative assessment of dispersion on profibrogenic responses in tissue culture cells and …