Activation and propagation of tumor-infiltrating lymphocytes on clinical-grade designer artificial antigen-presenting cells for adoptive immunotherapy of melanoma
Purpose: Adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL) is a
therapy for metastatic melanoma with response rates of up to 50%. However, the generation …
therapy for metastatic melanoma with response rates of up to 50%. However, the generation …
Trial watch: adoptively transferred cells for anticancer immunotherapy
Immunotherapies aimed at strengthening immune effector responses against malignant
cells are growing at exponential rates. Alongside, the impressive benefits obtained by …
cells are growing at exponential rates. Alongside, the impressive benefits obtained by …
Generation of autologous tumor-specific T cells for adoptive transfer based on vaccination, in vitro restimulation and CD3/CD28 dynabead-induced T cell expansion
MK Brimnes, AO Gang, M Donia, P thor Straten… - Cancer Immunology …, 2012 - Springer
Adoptive cell transfer (ACT) of in vitro expanded autologous tumor-infiltrating lymphocytes
(TIL) has been shown to exert therapeutic efficacy in melanoma patients. We aimed to …
(TIL) has been shown to exert therapeutic efficacy in melanoma patients. We aimed to …
[HTML][HTML] Neoantigen-specific Cd4+ tumor-infiltrating lymphocytes are potent effectors identified within adoptive cell therapy products for metastatic Melanoma patients
MLS Hall, JK Teer, X Yu, H Branthoover… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) is a
promising immunotherapeutic approach for patients with advanced solid tumors. While …
promising immunotherapeutic approach for patients with advanced solid tumors. While …
Enrichment of CD8+ cells from melanoma tumor-infiltrating lymphocyte cultures reveals tumor reactivity for use in adoptive cell therapy
PA Prieto, KH Durflinger, JR Wunderlich… - Journal of …, 2010 - journals.lww.com
Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) for metastatic
melanoma has shown objective response rates as high as 72%. The successful application …
melanoma has shown objective response rates as high as 72%. The successful application …
Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
JA Chacon, AA Sarnaik, JQ Chen, C Creasy… - Clinical Cancer …, 2015 - AACR
Purpose: Cultured tumor fragments from melanoma metastases have been used for years as
a source of tumor-infiltrating lymphocytes (TIL) for adoptive cell therapy (ACT). The …
a source of tumor-infiltrating lymphocytes (TIL) for adoptive cell therapy (ACT). The …
Adoptive cell transfer therapy for melanoma
T Inozume - Experimental Dermatology, 2023 - Wiley Online Library
Adoptive cell transfer (ACT) of tumor‐infiltrating lymphocytes (TILs) for melanoma is an
example of the most successful cancer immune therapy. It achieves a durable complete …
example of the most successful cancer immune therapy. It achieves a durable complete …
Expanded tumor-infiltrating lymphocytes from soft tissue sarcoma have tumor-specific function
JE Mullinax, ML Hall, M Beatty, AM Weber… - Journal of …, 2021 - journals.lww.com
Adoptive cell transfer (ACT) with tumor-infiltrating lymphocytes (TILs) can generate durable
clinical responses in patients with metastatic melanoma and ongoing trials are evaluating …
clinical responses in patients with metastatic melanoma and ongoing trials are evaluating …
Tumor-infiltrating lymphocyte therapy for melanoma: rationale and issues for further clinical development
GC Sim, J Chacon, C Haymaker, K Ritthipichai… - BioDrugs, 2014 - Springer
Cancer immunotherapy has become an important area for the future development of cancer
therapy; this includes T-cell-based therapies that involve adoptive transfer of autologous T …
therapy; this includes T-cell-based therapies that involve adoptive transfer of autologous T …
Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2
Adoptive cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has shown
significant clinical benefit, but is limited by toxicities due to a requirement for post-infusion …
significant clinical benefit, but is limited by toxicities due to a requirement for post-infusion …