Is the core function of orbitofrontal cortex to signal values or make predictions?

J Zhou, MPH Gardner, G Schoenbaum - Current Opinion in Behavioral …, 2021 - Elsevier
One dominant hypothesis about the function of the orbitofrontal cortex (OFC) is that the OFC
signals the subjective values of possible outcomes to other brain areas for learning and …

Does the orbitofrontal cortex signal value?

G Schoenbaum, Y Takahashi, TL Liu… - Annals of the New …, 2011 - Wiley Online Library
The orbitofrontal cortex (OFC) has long been implicated in associative learning. Early work
by Mishkin and Rolls showed that the OFC was critical for rapid changes in learned …

Taking stock of value in the orbitofrontal cortex

EB Knudsen, JD Wallis - Nature Reviews Neuroscience, 2022 - nature.com
People with damage to the orbitofrontal cortex (OFC) have specific problems making
decisions, whereas their other cognitive functions are spared. Neurophysiological studies …

A state representation for reinforcement learning and decision-making in the orbitofrontal cortex

NW Schuck, R Wilson, Y Niv - Goal-directed decision making, 2018 - Elsevier
Despite decades of research, the exact ways in which the orbitofrontal cortex (OFC)
influences cognitive function have remained mysterious. Anatomically, the OFC is …

The orbitofrontal cortex and the computation of subjective value: consolidated concepts and new perspectives

C Padoa‐Schioppa, X Cai - Annals of the New York Academy …, 2011 - Wiley Online Library
Remarkable progress has been made in recent years toward understanding the functions of
the orbitofrontal cortex (OFC). The finding that neurons in this area encode the subjective …

Medial orbitofrontal neurons preferentially signal cues predicting changes in reward during unblocking

N Lopatina, MA McDannald, CV Styer… - Journal of …, 2016 - Soc Neuroscience
The orbitofrontal cortex (OFC) has been broadly implicated in the ability to use the current
value of expected outcomes to guide behavior. Although value correlates have been …

Orbitofrontal neurons acquire responses to 'valueless' Pavlovian cues during unblocking

MA McDannald, GR Esber, MA Wegener, HM Wied… - Elife, 2014 - elifesciences.org
The orbitofrontal cortex (OFC) has been described as signaling outcome expectancies or
value. Evidence for the latter comes from the studies showing that neural signals in the OFC …

The orbitofrontal cortex, predicted value, and choice

BW Balleine, BK Leung… - Annals of the New York …, 2011 - Wiley Online Library
Considerable evidence suggests that choice between goal‐directed actions depends on two
incentive processes encoding the reward value of the goal or outcome and the predicted …

The role of orbitofrontal cortex in decision making: a component process account

LK Fellows - Annals of the New York Academy of Sciences, 2007 - Wiley Online Library
Clinical accounts of the effects of damage to orbitofrontal cortex (OFC) have provided
important clues about the functions of this region in humans. Patients with OFC injury can …

Cross-species studies of orbitofrontal cortex and value-based decision-making

JD Wallis - Nature neuroscience, 2012 - nature.com
Recent work has emphasized the role that orbitofrontal cortex (OFC) has in value-based
decision-making. However, it is also clear that a number of discrepancies have arisen when …