BAG3 is a cellular protein that is expressed predominantly in skeletal and cardiac muscle
but can also be found in the brain and in the peripheral nervous system. BAG3 functions in …

Nonischemic dilated cardiomyopathy is a common form of heart muscle disease in which
genetic factors play a critical etiological role. In this regard, both rare disease‐causing …

The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most
prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it …

Dilated cardiomyopathy (DCM) is a major cause of heart failure, characterized by ventricular
dilatation and systolic dysfunction. Familial DCM is reportedly caused by mutations in more …

Bcl-2-associated athanogene 3 (BAG3) is a cochaperone protein and a central player of the
cellular protein quality control system. BAG3 is prominently expressed in the heart and plays …

Defective protein quality control (PQC) systems are implicated in multiple diseases.
Molecular chaperones and co-chaperones play a central role in functioning PQC. Constant …

Abstract Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid anti-apoptotic protein
that is constitutively expressed in the heart. BAG3 mutations, including mutations leading to …

Background BAG3 gene mutations have been recently implicated as a novel cause of
dilated cardiomyopathy (DCM). Our aim was to evaluate the prevalence of BAG3 mutations …

Dear Editor, Bcl-2-associated athanogene 3 (BAG3) protein belongs to the family of co-
chaperones that interact with the ATPase domain of the heat shock protein HSP70 through …

The most common cause of dilated cardiomyopathy and heart failure (HF) is ischemic heart
disease; however, in a third of all patients the cause remains undefined and patients are …