Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes

L Sobrin, S Ripke, Y Yu, J Fagerness, TR Bhangale… - Ophthalmology, 2012 - Elsevier
PURPOSE: To investigate whether the 2 subtypes of advanced age-related macular
degeneration (AMD), choroidal neovascularization (CNV), and geographic atrophy (GA) …

Differences in the genetic susceptibility to age-related macular degeneration clinical subtypes

L Shen, TJ Hoffmann, RB Melles… - … & visual science, 2015 - iovs.arvojournals.org
Purpose: We compared across age-related macular degeneration (AMD) subtypes the effect
of AMD risk variants, their predictive power, and heritability. Methods: The prevalence of …

Genome-wide analysis of disease progression in age-related macular degeneration

Q Yan, Y Ding, Y Liu, T Sun, LG Fritsche… - Human molecular …, 2018 - academic.oup.com
Family-and population-based genetic studies have successfully identified multiple disease-
susceptibility loci for Age-related macular degeneration (AMD), one of the first batch and …

Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors

Y Chen, J Zeng, C Zhao, K Wang, E Trood… - Archives of …, 2011 - jamanetwork.com
Objectives To evaluate the independent and joint effects of genetic factors and
environmental variables on advanced forms of age-related macular degeneration (AMD) …

Predictive performance of an updated polygenic risk score for age-related macular degeneration

C Yu, L Robman, W He, RL Woods, R Wolfe, J Phung… - Ophthalmology, 2024 - Elsevier
Purpose A recent genome-wide association study of age-related macular degeneration
(AMD) identified new AMD-associated risk variants. These variants now can be incorporated …

[HTML][HTML] Development of a genotype assay for age-related macular degeneration: the EYE-RISK Consortium

A de Breuk, IE Acar, E Kersten, MM Schijvenaars… - Ophthalmology, 2021 - Elsevier
Purpose To develop a genotype assay to assess associations with common and rare age-
related macular degeneration (AMD) risk variants, to calculate an overall genetic risk score …

Rare and common genetic variants, smoking, and body mass index: progression and earlier age of developing advanced age-related macular degeneration

JM Seddon, R Widjajahakim… - … Ophthalmology & Visual …, 2020 - iovs.arvojournals.org
Purpose: To determine behavioral and genetic factors associated with incidence and age of
progression to advanced age-related macular degeneration (AMD), geographic atrophy …

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

TW Winkler, F Grassmann, C Brandl, C Kiel… - BMC medical …, 2020 - Springer
Background Advanced age-related macular degeneration (AMD) is a leading cause of
blindness. While around half of the genetic contribution to advanced AMD has been …

Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease

GR Abecasis, BM Yashar, Y Zhao… - The American Journal of …, 2004 - cell.com
Age-related macular degeneration (AMD) is a complex multifactorial disease that affects the
central region of the retina. AMD is clinically heterogeneous, leading to geographic atrophy …

A deep phenotype association study reveals specific phenotype associations with genetic variants in age-related macular degeneration: Age-Related Eye Disease …

F van Asten, M Simmons, A Singhal, TD Keenan… - Ophthalmology, 2018 - Elsevier
Purpose Age-related macular degeneration (AMD), a multifactorial disease with variable
phenotypic presentation, was associated with 52 single nucleotide polymorphisms (SNPs) at …