Experimental observations performed in the p53-Mdm2 network, one of the key protein
modules involved in the control of proliferation of abnormal cells in mammals, revealed the …

We investigate the dynamical properties of a simple four-variable model describing the
interactions between the tumour suppressor protein p53, its main negative regulator Mdm2 …

In Part I of this work, we carried out a logical analysis of a simple model describing the
interplay between protein p53, its main negative regulator Mdm2 and DNA damage, and …

In this paper we investigate the role of spatial effects in determining the dynamics of a
subclass of signalling pathways characterised by their ability to demonstrate oscillatory …

The p53 network is perhaps the most important pathway involved in preventing the initiation
ofcancer. p53levels and activity are upregulated in response to various stresses including …

The recent experiments on the dynamics of a common biological network motif, p53 and
Mdm2 feedback loop, have shown the oscillatory behaviors for the activities of p53 and …

The tumor suppressor protein, p53, is a major guardian of genomic integrity in human cells
(Hanahan and Weinberg, 2000). When DNA is damaged by ionizing radiation (as a result …

p53 is activated in response to events compromising the genetic integrity of a cell. Recent
data show that p53 activity does not increase steadily with genetic damage but rather …

We previously proposed an integrated computational model for the network of cyclin-
dependent kinases (Cdks) that controls the dynamics of the mammalian cell cycle [C. Gérard …

Oscillatory behaviours in genetic networks are important examples for studying the
principles underlying the dynamics of cellular regulation. Recently the team of Alon has …