Noncovalent interactions between aromatic nucleobases are the major stabilizing forces
which contribute to the structural integrity of duplex DNA and RNA. 1–3 However, base …

Noncovalent interactions between aromatic molecules are widely believed to be important
contributing factors in the stabilization of organized structure in biological macromolecules …

The stabilizing effect of a dG: dC base-pair can also be imparted to a DNA duplex by a non-
hydrogen-bonding, non-shape-complementary nucleoside analogue when interstrand …

In itsmost general form, the Watson-Crick base pair joins a six-membered heterocyclic ring
(in natural oligonucleotides, a pyrimidine) with a five-six fused ring system (in natural …

We report the properties of hydrophobic isosteres of pyrimidines and purines in synthetic
DNA duplexes. Phenyl nucleosides 1 and 2 are nonpolar isosteres of the natural thymidine …

Hydrogen-bonding and stacking interactions between nucleobases are considered to be the
major noncovalent interactions that stabilize the DNA and RNA double helices. In recent …

Due to their selective complementary base-association phenomena and their enhanced
resistance against enzymatic degradation, DNA analogs attract considerable attention as …

We describe the preparation and structure of the deoxyribonucleoside of 4-fluoro-6-
methylbenzimidazole, abbreviated dH (8), which acts as a close shape mimic of the …

We describe the properties in DNA of a set of five nonpolar nucleoside mimics in which
shape is similar but size is increased gradually. The compounds vary in the size of their …

Base pairing is a pivotal process in nature. Genetic information is passed on by the
formation of pairs between complementary nucleobases.[1, 2] The detection of DNA or RNA …