Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I)
exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted …

PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular
pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly …

Adenosine deaminase acting on RNA 1 (ADAR1) catalyzes RNA editing of cellular and viral
RNAs. Besides RNA editing, ADAR1 has recently been shown to play important roles in …

Phosphorylation-dependent ubiquitination and degradation of the IFNAR1 chain of the type I
interferon (IFN) receptor is regulated by two different pathways, one of which is ligand …

Type 1 interferons (IFN1) elicit antiviral defenses by activating the cognate receptor
composed of IFN-α/β receptor chain 1 (IFNAR1) and IFNAR2. Down-regulation of this …

STAT1 is a critical transcription factor for regulating host antiviral defenses. STAT1 activation
is largely dependent on phosphorylation at tyrosine 701 site of STAT1 (pY701-STAT1) …

Viral infection triggers a series of signaling cascades, which converge to activate the
transcription factors nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3) …

Abstract Ataxin-3 (ATXN3) belongs to the Josephin family of deubiquitinases. So far, ATXN3
is majorly linked to the neurodegenerative disease, Machado–Joseph disease. The role of …

Innate immune cells are critical in protective immunity against viral infections, involved in
sensing foreign viral nucleic acids. Here we report that the poly (ADP-ribose) polymerase 9 …

The IFN immune system comprises type I, II, and III IFNs, signals through the JAK-STAT
pathway, and plays central roles in host defense against viral infection. Posttranslational …