Aptamers and their applications in nanomedicine

H Sun, Y Zu - Small, 2015 - Wiley Online Library
Aptamers are composed of short RNA or single‐stranded DNA sequences that, when folded
into their unique 3D conformation, can bind to their targets with high specificity and affinity …

Aptamer-guided nanomedicines for anticancer drug delivery

W Alshaer, H Hillaireau, E Fattal - Advanced drug delivery reviews, 2018 - Elsevier
Aptamers are versatile nucleic acid-based macromolecules characterized by their high
affinity and specificity to a specific target. Taking advantage of such binding properties …

Aptamer-based targeted drug delivery systems: current potential and challenges

F He, N Wen, D Xiao, J Yan, H Xiong… - Current medicinal …, 2020 - ingentaconnect.com
Aptamers are single-stranded DNA or RNA with 20-100 nucleotides in length that can
specifically bind to target molecules via formed three-dimensional structures. These …

Nanotechnology and aptamers: applications in drug delivery

E Levy-Nissenbaum, AF Radovic-Moreno… - Trends in …, 2008 - cell.com
Nucleic acid ligands, also known as aptamers, are a class of macromolecules that are being
used in several novel nanobiomedical applications. Aptamers are characterized by high …

Recent advancements of aptamers in cancer therapy

S Venkatesan, K Chanda, MM Balamurali - ACS omega, 2023 - ACS Publications
Aptamers are chemical antibodies possessing the capability of overcoming the limitations
posed by conventional antibodies, particularly for diagnostic, therapeutic, and theranostic …

[HTML][HTML] Aptamer-enabled nanomaterials for therapeutics, drug targeting and imaging

M Liu, L Wang, Y Lo, SCC Shiu, AB Kinghorn… - Cells, 2022 - mdpi.com
A wide variety of nanomaterials have emerged in recent years with advantageous properties
for a plethora of therapeutic and diagnostic applications. Such applications include drug …

Molecular aptamers for drug delivery

W Tan, H Wang, Y Chen, X Zhang, H Zhu, C Yang… - Trends in …, 2011 - cell.com
The active targeting of drugs in a cell-, tissue-or disease-specific manner represents a
potentially powerful technology with widespread applications in medicine, including the …

Applications of cancer cell-specific aptamers in targeted delivery of anticancer therapeutic agents

M Kim, DM Kim, KS Kim, W Jung, DE Kim - Molecules, 2018 - mdpi.com
Aptamers are single-stranded oligonucleotides that specifically bind and interact with their
corresponding targets, including proteins and cells, through unique three-dimensional …

Nucleic acid aptamer‐mediated drug delivery for targeted cancer therapy

H Zhu, J Li, XB Zhang, M Ye, W Tan - ChemMedChem, 2015 - Wiley Online Library
Aptamers are emerging as promising therapeutic agents and recognition elements. In
particular, cell‐SELEX (systematic evolution of ligands by exponential enrichment) allows in …

Aptamer nanomedicine for cancer therapeutics: barriers and potential for translation

YH Lao, KKL Phua, KW Leong - ACS nano, 2015 - ACS Publications
Aptamer nanomedicine, including therapeutic aptamers and aptamer nanocomplexes, is
beginning to fulfill its potential in both clinical trials and preclinical studies. Especially in …