Prolongation of cardiac action potentials may mediate some of the arrhythmia-suppressing
and arrhythmia-aggravating actions of antiarrhythmic agents. In this study, suppression of …

Effects of quinidine on membrane currents forming the plateau of action potentials were
studied using an isolated single ventricular cell from guinea-pig hearts. Quinidine (5 mg/l) …

We examined the effects of quinidine (5-20 microM) on transmembrane action potentials
and ionic currents of isolated canine ventricular myocytes. Collagenase treatment of canine …

1 The effects of quinidine on calcium‐independent outward K+ currents in rat ventricular
myocytes were studied using whole‐cell patch clamp techniques. 2 Quinidine sulphate (6 …

In guinea pig cardiac myocytes quinidine (20 microM) caused less than 10% tonic block
reduction of the sodium current at-120 mV, but a fast pulse train reduced it more than 90 …

A major action of the antiarrhythmic agent quinidine is prolongation of cardiac repolarization.
In these experiments, the time-dependent effects of quinidine on the delayed rectifier …

The mechanism of drug-induced inhibition of the transient outward current, I to, has been
investigated in rat ventricular myocytes using the whole cell patch clamp technique. I to was …

Quinidine is frequently used as a class I antiarrhythmic agent in the management of cardiac
rhythm disturbances. It depresses the rapid initial depolarization of the action potential by …

The acute and chronic effects of amiodarone were studied on the transmembrane ionic
currents in rabbit single ventricular myocytes at 35 degrees C by applying the whole-cell …

Objectives The effects of almokalant (4-[3-ethyl [3-(propylsulphinyl) propyl]-amino]-2-hydroxy-
propoxyj-benzonitrile), E-4031 (1-[2-(6-methyl-2-pyridyl)-ethyl]-4-(4-methylsulphonyl-amino …