We have developed an effective bacterial cancer therapy strategy by targeting viable tumor
tissue using Salmonella typhimurium auxotrophs that we have generated which grow in …

A paradigm change in the treatment of cancer is urgently needed. Bacteria offer many
advantages, including natural cytotoxity, motility, chemotaxis and a relative large genome to …

We report here a modified auxotrophic strain of Salmonella typhimurium that can target and
cure breast tumors in orthotopic mouse models. We have previously reported development …

Here we report a genetically modified bacteria strain, Salmonella typhimurium A1, selected
for anticancer activity in vivo. The strain grows in tumor xenografts. In sharp contrast, normal …

The present chapter reviews the development of the tumor-targeting amino-acid auxotrophic
strain S. typhimurium A1 and the in vivo selection and characterization of the high-tumor …

Salmonella typhimurium double leu-arg auxotrophs have been shown to be highly effective
as antitumor agents in nude mouse models of human metastatic cancer. In order to proceed …

Cancer metastasis is the life‐threatening aspect of cancer and is usually resistant to
standard treatment. We report here a targeted therapy strategy for cancer metastasis using a …

Cancer of the exocrine pancreas is the fourth leading cause of cancer deaths in the United
States. Currently, surgical resection is the only hope for cure. The majority of patients …

We report here a tumor-targeting strategy for pancreatic cancer using a modified auxotrophic
strain of Salmonella typhimurium. The genetically-modified strain of S. typhimurium requires …

We developed tumor-targeting Salmonella typhimurium (S. typhimurium) A1-R, a facultative
anaerobe that is an auxotroph of leucine and arginine. The tumor-targeting efficacy of S …