Gram‐negative bacteria remain clinically important pathogens in both hospital and
community settings. Recent research indicates that efflux pumps play a prominent role in the …

Pseudomonas aeruginosa is an opportunistic human pathogen characterized by an innate
resistance to multiple antimicrobial agents. A major contribution to this intrinsic multidrug …

The mexCD-oprJ and mexAB-oprM operons encode components of two distinct multidrug
efflux pumps in Pseudomonas aeruginosa. To assess the contribution of individual …

ABSTRACT The MexAB-OprM multidrug efflux system exports a number of antimicrobial
compounds, including β-lactams. In an attempt to define more fully the range of antimicrobial …

Pseudomonas aeruginosa expresses a low level of the MexAB-OprM efflux pump and
shows natural resistance to many structurally and functionally diverse antibiotics. The …

Objectives: Multidrug efflux pumps are thought to be involved in mediating multidrug
resistance in Pseudomonas aeruginosa. Here we aim to characterize hitherto …

MexAB-OprM is a constitutively expressed multidrug efflux system of Pseudomonas
aeruginosa. Using isogenic pump mutants, the contributions of the MexAB-OprM efflux pump …

Whole-cell assays were implemented to search for efflux pump inhibitors (EPIs) of the three
multidrug resistance efflux pumps (MexAB-OprM, MexCD-OprJ, MexEF-OprN) that contribute …

We have earlier described mexA-mexB-oprK, an operon involved in pyoverdine export in
Pseudomonas aeruginosa, and suggested that the products of these genes also contribute …

Pseudomonas aeruginosa is an opportunistic human pathogen characterized by an intrinsic
resistance to multiple antimicrobial agents and the ability to develop high-level (acquired) …