Rapid cerebral amyloid binding by Aβ antibodies infused into β-amyloid precursor protein transgenic mice
DT Winkler, D Abramowski, S Danner, M Zurini… - Biological …, 2010 - Elsevier
BACKGROUND: Passive immunization for the treatment of Alzheimer's disease (AD) was
rapidly translated into clinical trials. However, basic mechanisms of AD immunotherapy …
rapidly translated into clinical trials. However, basic mechanisms of AD immunotherapy …
Autoantibodies to amyloid β-peptide (Aβ) are increased in Alzheimer's disease patients and Aβ antibodies can enhance Aβ neurotoxicity: implications for disease …
Studies of amyloid precursor protein transgenic mice suggest that immune responses to
amyloid β peptide (Aβ) may be instrumental in the removal of plaques from the brain, but the …
amyloid β peptide (Aβ) may be instrumental in the removal of plaques from the brain, but the …
Peripheral and central biodistribution of 111In-labeled anti-beta-amyloid autoantibodies in a transgenic mouse model of Alzheimer's disease
Active as well as passive immunization against beta-amlyoid (Aβ) has been proposed as a
treatment to lower cerebral amyloid burden and stabilize cognitive decline in Alzheimer's …
treatment to lower cerebral amyloid burden and stabilize cognitive decline in Alzheimer's …
Amyloid-β immunotherapy for Alzheimer's disease
HJ Fu, B Liu, JL Frost… - CNS & Neurological …, 2010 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive, degenerative disorder of the brain and the most
common form of dementia among the elderly. As the population grows and lifespan is …
common form of dementia among the elderly. As the population grows and lifespan is …
Naturally occurring autoantibodies against β-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease
R Dodel, K Balakrishnan, K Keyvani… - Journal of …, 2011 - Soc Neuroscience
Alzheimer's disease (AD) is a neurodegenerative disorder primarily affecting regions of the
brain responsible for higher cognitive functions. Immunization against β-amyloid (Aβ) in …
brain responsible for higher cognitive functions. Immunization against β-amyloid (Aβ) in …
Sustained levels of antibodies against Aβ in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice
F Bard, M Fox, S Friedrich, P Seubert, D Schenk… - Experimental …, 2012 - Elsevier
Passive immunization with anti-Aβ antibodies leads to the reduction of AD-like
neuropathology in transgenic mice. Previously we showed that anti-Aβ antibodies enter the …
neuropathology in transgenic mice. Previously we showed that anti-Aβ antibodies enter the …
Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
T Gustavsson, NG Metzendorf, E Wik… - Alzheimer's Research & …, 2023 - Springer
Background Brain-directed immunotherapy is a promising strategy to target amyloid-β (Aβ)
deposits in Alzheimer's disease (AD). In the present study, we compared the therapeutic …
deposits in Alzheimer's disease (AD). In the present study, we compared the therapeutic …
Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor …
Background In prior work we detected reduced anti-Aβ antibody titers in Aβ-vaccinated
transgenic mice expressing the human amyloid precursor protein (APP) compared to …
transgenic mice expressing the human amyloid precursor protein (APP) compared to …
Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model
J Morales-Corraliza, SD Schmidt, MJ Mazzella… - Neurobiology of …, 2013 - Elsevier
Although anti-human β-amyloid (Aβ) immunotherapy clears brain β-amyloid plaques in
Alzheimer's disease (AD), targeting additional brain plaque constituents to promote …
Alzheimer's disease (AD), targeting additional brain plaque constituents to promote …
[HTML][HTML] Limited clearance of pre-existing amyloid plaques after intracerebral injection of Aβ antibodies in two mouse models of Alzheimer's disease
SMF Tucker, DR Borchelt… - Journal of neuropathology …, 2008 - ncbi.nlm.nih.gov
Recent studies have demonstrated the potential utility of antibodies for the treatment of
Alzheimer's disease (AD). In transgenic mouse models of AD, peripheral and intracerebral …
Alzheimer's disease (AD). In transgenic mouse models of AD, peripheral and intracerebral …