Clinical Strains of Pseudomonas aeruginosa Overproducing MexAB-OprM and MexXY Efflux Pumps Simultaneously

C Llanes, D Hocquet, C Vogne… - Antimicrobial agents …, 2004 - Am Soc Microbiol
Simultaneous overexpression of the MexAB-OprM and MexXY efflux systems was
demonstrated by real-time reverse transcription-PCR and immunoblotting experiments for …

In Vivo Emergence of Multidrug-Resistant Mutants ofPseudomonas aeruginosa Overexpressing the Active Efflux System MexA-MexB-OprM

I Ziha-Zarifi, C Llanes, T Köhler… - Antimicrobial Agents …, 1999 - Am Soc Microbiol
ABSTRACT During a 6-month period, 21 pairs of Pseudomonas aeruginosa isolates
susceptible (pretherapy) and resistant (posttherapy) to antipseudomonal β-lactam antibiotics …

Contribution of the MexX-MexY-OprM Efflux System to Intrinsic Resistance in Pseudomonas aeruginosa

N Masuda, E Sakagawa, S Ohya, N Gotoh… - Antimicrobial agents …, 2000 - Am Soc Microbiol
To test the possibility that MexX-MexY, a new set of efflux system components, is associated
with OprM and contributes to intrinsic resistance in Pseudomonas aeruginosa, we …

Two Efflux Systems Expressed Simultaneously in Multidrug-Resistant Pseudomonas aeruginosa

L Pumbwe, LJV Piddock - Antimicrobial Agents and …, 2000 - Am Soc Microbiol
ABSTRACT Simultaneous overexpression of MexAB-OprM and MexEF-OprN was
demonstrated for a multiply antibiotic-resistant clinical isolate of Pseudomonas aeruginosa …

Expression of Pseudomonas aeruginosa Multidrug Efflux Pumps MexA-MexB-OprM and MexC-MexD-OprJ in a Multidrug-Sensitive Escherichia coli Strain

R Srikumar, T Kon, N Gotoh… - Antimicrobial agents and …, 1998 - Am Soc Microbiol
The mexCD-oprJ and mexAB-oprM operons encode components of two distinct multidrug
efflux pumps in Pseudomonas aeruginosa. To assess the contribution of individual …

Influence of Mutations in the mexR Repressor Gene on Expression of the MexA-MexB-OprM Multidrug Efflux System ofPseudomonas aeruginosa

R Srikumar, CJ Paul, K Poole - Journal of Bacteriology, 2000 - Am Soc Microbiol
Several nalB-type multidrug-resistant mutants of Pseudomonas aeruginosa overexpressed
MexAB-OprM and carried mutations in the local regulatory gene, mexR. Others, dubbed …

Variation of the mexT gene, a regulator of the MexEF-OprN efflux pump expression in wild-type strains of Pseudomonas aeruginosa

H Maseda, K Saito, A Nakajima… - FEMS microbiology …, 2000 - academic.oup.com
We found three variations of wild-type strains in terms of mexT-mediated regulation of the
MexEF-OprN efflux pump, in which overexpression of the pump results in nfxC-type …

Mutations in PA3574 (nalD) Lead to Increased MexAB-OprM Expression and Multidrug Resistance in Laboratory and Clinical Isolates of Pseudomonas aeruginosa

ML Sobel, D Hocquet, L Cao, P Plesiat… - Antimicrobial Agents …, 2005 - Am Soc Microbiol
Mutations in genes mexR and nalC have previously been shown to drive overexpression of
the MexAB-OprM multidrug efflux system in Pseudomonas aeruginosa. A transposon …

Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa

XZ Li, H Nikaido, K Poole - Antimicrobial agents and …, 1995 - Am Soc Microbiol
We have earlier described mexA-mexB-oprK, an operon involved in pyoverdine export in
Pseudomonas aeruginosa, and suggested that the products of these genes also contribute …

[HTML][HTML] Expression of the MexXY efflux pump in amikacin-resistant isolates of Pseudomonas aeruginosa

S Islam, S Jalal, B Wretlind - Clinical microbiology and infection, 2004 - Elsevier
ABSTRACT The MexZ–MexX–MexY multidrug efflux system in Pseudomonas aeruginosa
was studied to determine its contribution to aminoglycoside resistance. Amikacin-resistant …