We report here a new targeting strategy for primary bone tumor and lung metastasis with a
modified auxotrophic strain of Salmonella typhimurium. We have previously developed the …

We report here a modified auxotrophic strain of Salmonella typhimurium that can target and
cure breast tumors in orthotopic mouse models. We have previously reported development …

The present chapter reviews the development of the tumor-targeting amino-acid auxotrophic
strain S. typhimurium A1 and the in vivo selection and characterization of the high-tumor …

We report here a tumor-targeting strategy for pancreatic cancer using a modified auxotrophic
strain of Salmonella typhimurium. The genetically-modified strain of S. typhimurium requires …

Here we report a genetically modified bacteria strain, Salmonella typhimurium A1, selected
for anticancer activity in vivo. The strain grows in tumor xenografts. In sharp contrast, normal …

Previously, a patient-derived orthotopic xenograft (PDOX) model was established with a
lung metastasis from an osteosarcoma patient which developed after adjuvant cisplatinum …

Salmonella typhimurium double leu-arg auxotrophs have been shown to be highly effective
as antitumor agents in nude mouse models of human metastatic cancer. In order to proceed …

We have developed the genetically-modified Salmonella typhimurium A1-R strain that
selectively targets tumors. S. typhimurium A1-R is auxotrophic for Leu and Arg, which …

Prognosis of patients with lung metastases of soft-tissue sarcoma is still poor. Therefore,
novel systemic therapy is needed to improve the survival of soft-tissue sarcoma. In the …

We have developed an effective bacterial cancer therapy strategy by targeting viable tumor
tissue using Salmonella typhimurium auxotrophs that we have generated which grow in …