In Vitro, In Silico and Network Pharmacology Mechanistic Approach to Investigate the α-Glucosidase Inhibitors Identified by Q-ToF-LCMS from Phaleria macrocarpa Fruit …

MAR Mia, QU Ahmed, S Ferdosh, ABM Helaluddin… - Metabolites, 2022 - mdpi.com
The fruit of Phaleria macrocarpa have been traditionally used as an antidiabetic remedy in
Malaysia and neighbouring countries. Despite its potential for diabetes treatment, no …

Metabolomics combined with chemometric analysis to identify α-glucosidase inhibitors in Phaleria macrocarpa fruit extracts and its molecular docking simulation

S Easmin, ZI Sarker, A Khatib, S Ferdosh, J Jaffri… - South African Journal of …, 2024 - Elsevier
Phaleria macrocarpa is a medicinal plant widely available in Malaysia. The plant parts have
been traditionally used as an antidiabetic remedy. This study aimed to identify the putative …

Analyzing the potential of selected plant extracts and their structurally diverse secondary metabolites for α-glucosidase inhibitory activity: in vitro and in silico …

MD Ojha, A Yadav, HP - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
Inhibiting α-glucosidase activity is a therapeutic method to regulate post-prandial
hyperglycemia in humans. Here, in-vitro and in-silico studies were used to find α …

[PDF][PDF] α-glucosidase inhibitory activity of compounds from the essential oil of Leucas lavandulifolia Sm.: insights from GC-MS analysis and molecular docking studies

P Thanait, S Dhital, N Parajuli, M Poudel… - Asian J. Chem …, 2024 - researchgate.net
Diabetes, a chronic metabolic disorder, characterized by elevated blood sugar levels is a
burning issue of the 21st century. This problem can be managed by inhibiting the normal …

Bioactivity-guided separation of potential α-glycosidase inhibitor from clerodendranthus spicatus based on HSCCC coupled with molecular docking

C Zhu, H Niu, A Nie, M Bian - Scientific Reports, 2021 - nature.com
Clerodendranthus Spicatus is a traditional Dais medi-edible plant and it has been proven to
have good blood glucose-lowering efficacy. However, the material basis of …

Lawsonia inermis flower aqueous extract expressed better anti-alpha-glucosidase and anti-acetylcholinesterase activity and their molecular dynamics

I Shahanaj, J Ramakrishnan, K Poomani… - Journal of …, 2023 - Taylor & Francis
Lawsonia inermis (henna) has been used in traditional medicine throughout the world and
biological property of its flower has been least explored. In the present study, the …

Investigation of Yacon Leaves (Smallanthus sonchifolius) for α-Glucosidase Inhibitors Using Metabolomics and In Silico Approach

Z Aziz, ND Yuliana, P Simanjuntak, M Rafi… - Plant Foods for Human …, 2021 - Springer
Abstract Yacon (Smallanthus sonchifolius (Poepp.) H. Robinson) leaves is traditionally
consumed as herbal tea in many countries including Indonesia. This plant's antidiabetic …

Characterization of α-Glucosidase Inhibitors from Psychotria malayana Jack Leaves Extract Using LC-MS-Based Multivariate Data Analysis and In-Silico Molecular …

TS Nipun, A Khatib, Z Ibrahim, QU Ahmed, IE Redzwan… - Molecules, 2020 - mdpi.com
Psychotria malayana Jack has traditionally been used to treat diabetes. Despite its potential,
the scientific proof in relation to this plant is still lacking. Thus, the present study aimed to …

Identification of alpha-glucosidase enzyme inhibitors from phytochemicals via integrated deep learning, molecular docking, molecular dynamics simulation, and …

P Sharma, V Sharma, S Mathpal, D Tewari… - South African Journal of …, 2024 - Elsevier
Alpha-glucosidase is a crucial enzyme involved in carbohydrate metabolism, and inhibiting
its activity holds promise for treating Type 2 Diabetes Mellitus (T2DM). This study aimed to …

Discovery of α-amylase and α-glucosidase dual inhibitors from NPASS database for management of Type 2 Diabetes Mellitus: A chemoinformatic approach

W Ndarawit, CO Ochieng, D Angwenyi, JN Cruz… - PloS one, 2024 - journals.plos.org
Postprandial hyperglycemia, typical manifestation of Type 2 Diabetes Mellitus (T2DM), is
associated with notable global morbidity and mortality. Preventing the advancement of this …