Emerging metrology for high-throughput nanomaterial genotoxicology

BC Nelson, CW Wright, Y Ibuki… - …, 2017 - academic.oup.com
The rapid development of the engineered nanomaterial (ENM) manufacturing industry has
accelerated the incorporation of ENMs into a wide variety of consumer products across the …

Common considerations for genotoxicity assessment of nanomaterials

RK Elespuru, SH Doak, AR Collins, M Dusinska… - Frontiers in …, 2022 - frontiersin.org
Genotoxicity testing is performed to determine potential hazard of a chemical or agent for
direct or indirect DNA interaction. Testing may be a surrogate for assessment of heritable …

Genotoxicity assessment of nanomaterials: recommendations on best practices, assays, and methods

R Elespuru, S Pfuhler, MJ Aardema… - Toxicological …, 2018 - academic.oup.com
Nanomaterials (NMs) present unique challenges in safety evaluation. An international
working group, the Genetic Toxicology Technical Committee of the International Life …

Confounding experimental considerations in nanogenotoxicology

SH Doak, SM Griffiths, B Manshian, N Singh… - …, 2009 - academic.oup.com
The development of novel nanomaterials with unique physico-chemical properties is
increasing at a rapid rate, with potential applications across a broad range of manufacturing …

Genotoxicity of nanomaterials: refining strategies and tests for hazard identification

S Pfuhler, R Elespuru, MJ Aardema… - Environmental and …, 2013 - Wiley Online Library
A workshop addressing strategies for the genotoxicity assessment of nanomaterials (NMs)
was held on October 23, 2010 in Fort Worth Texas, USA. The workshop was organized by …

In vitro approaches for assessing the genotoxicity of nanomaterials

M Dusinska, E Mariussen, E Rundén-Pran… - … : methods and protocols, 2019 - Springer
Genotoxicity is associated with serious health effects and includes different types of DNA
lesions, gene mutations, structural chromosome aberrations involving breakage and/or …

Genotoxicity testing of nanomaterials

R Landsiedel, N Honarvar, SB Seiffert… - Wiley …, 2022 - Wiley Online Library
Nanomaterials have outstanding and unprecedented advantageous material properties but
may also cause adverse effects in humans upon exposure. Testing nanomaterials for …

Progress in genotoxicity evaluation of engineered nanomaterials

X Guo, T Chen - Nanomaterials-toxicity and risk assessment, 2015 - books.google.com
Engineered nanomaterials (ENMs) are being produced at an increasing rate. Because of
their unique physicochemical properties, ENMs have been used in a wide variety of …

[HTML][HTML] In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

SH Doak, B Manshian, GJS Jenkins, N Singh - Mutation Research/Genetic …, 2012 - Elsevier
There is a pressing requirement to define a hazard identification and risk management
strategy for nanomaterials due to the rapid growth in the nanotechnology industry and their …

Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report

SH Doak, C Andreoli, MJ Burgum, Q Chaudhry… - 2023 - academic.oup.com
Genotoxicity testing for nanomaterials remains challenging as standard testing approaches
require some adaptation, and further development of nano-specific OECD Test Guidelines …