Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50–95 years: a …
CR Jack, HJ Wiste, SD Weigand, TM Therneau… - The Lancet …, 2017 - thelancet.com
Background A new classification for biomarkers in Alzheimer's disease and cognitive ageing
research is based on grouping the markers into three categories: amyloid deposition (A) …
research is based on grouping the markers into three categories: amyloid deposition (A) …
Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross …
CR Jack, HJ Wiste, SD Weigand, WA Rocca… - The Lancet …, 2014 - thelancet.com
Summary Background As preclinical Alzheimer's disease becomes a target for therapeutic
intervention, the overlap between imaging abnormalities associated with typical ageing and …
intervention, the overlap between imaging abnormalities associated with typical ageing and …
Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study
Background New research criteria for preclinical Alzheimer's disease have been proposed,
which include stages for cognitively normal individuals with abnormal amyloid markers …
which include stages for cognitively normal individuals with abnormal amyloid markers …
Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study
Background Improved understanding is needed of risk factors and markers of disease
progression in preclinical Alzheimer's disease. We assessed associations between brain β …
progression in preclinical Alzheimer's disease. We assessed associations between brain β …
Prevalence of biologically vs clinically defined Alzheimer spectrum entities using the National Institute on Aging–Alzheimer's Association research framework
CR Jack, TM Therneau, SD Weigand, HJ Wiste… - JAMA …, 2019 - jamanetwork.com
Importance A National Institute on Aging–Alzheimer's Association (NIA-AA) workgroup
recently published a research framework in which Alzheimer disease is defined by …
recently published a research framework in which Alzheimer disease is defined by …
Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer's disease: a cross-sectional analysis of data from the …
Background Some people with substantial Alzheimer's disease pathology at autopsy had
shown few characteristic clinical symptoms or signs of the disease, whereas others with little …
shown few characteristic clinical symptoms or signs of the disease, whereas others with little …
Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study
CR Jack, TM Therneau, HJ Wiste, SD Weigand… - The Lancet …, 2016 - thelancet.com
Background In a 2014 cross-sectional analysis, we showed that amyloid and
neurodegeneration biomarker states in participants with no clinical impairment varied …
neurodegeneration biomarker states in participants with no clinical impairment varied …
Association of factors with elevated amyloid burden in clinically normal older individuals
Importance The Anti-Amyloid Treatment in Asymptomatic Alzheimer disease (A4) Study is an
ongoing prevention trial in clinically normal older individuals with evidence of elevated brain …
ongoing prevention trial in clinically normal older individuals with evidence of elevated brain …
Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer's disease: a prospective cohort study
Background The biomarker model of Alzheimer's disease postulates a dynamic sequence of
amyloidosis, neurodegeneration, and cognitive decline as an individual progresses from …
amyloidosis, neurodegeneration, and cognitive decline as an individual progresses from …
Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group
Summary In 2018, the US National Institute on Aging and the Alzheimer's Association
proposed a purely biological definition of Alzheimer's disease that relies on biomarkers …
proposed a purely biological definition of Alzheimer's disease that relies on biomarkers …