Huntington's disease gene product, huntingtin, associates with microtubules in vitro
T Tukamoto, N Nukina, K Ide, I Kanazawa - Molecular brain research, 1997 - Elsevier
The gene responsible for Huntington's disease produces a large protein with a molecular
weight of≈ 350 k, designated huntingtin. Here, we report that the protein can associate in …
weight of≈ 350 k, designated huntingtin. Here, we report that the protein can associate in …
Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with β-tubulin: relevance to Huntington's disease
Huntington's disease results from an expansion of a series of glutamine repeats in the
protein huntingtin. We have discovered from immunopurification studies that huntingtin …
protein huntingtin. We have discovered from immunopurification studies that huntingtin …
Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies.
The Huntington disease (HD) phenotype is associated with expansion of a trinucleotide
repeat in the IT15 gene, which is predicted to encode a 348-kDa protein named huntington …
repeat in the IT15 gene, which is predicted to encode a 348-kDa protein named huntington …
Molecular aspects of Huntington's disease
HW Walling, JJ Baldassare… - Journal of neuroscience …, 1998 - Wiley Online Library
Huntington's disease (HD) is a progressive neurodegenerative disease striking principally
medium spiny GABAergic neurons of the caudate nucleus of the basal ganglia. It affects …
medium spiny GABAergic neurons of the caudate nucleus of the basal ganglia. It affects …
Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats
SH Li, XJ Li - Human molecular genetics, 1998 - academic.oup.com
Huntington's disease (HD) is caused by expansion of a glutamine repeat in huntingtin.
Mutant huntingtin contains 36–55 repeats in adult HD patients and> 60 repeats in juvenile …
Mutant huntingtin contains 36–55 repeats in adult HD patients and> 60 repeats in juvenile …
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
M DiFiglia, E Sapp, K Chase, C Schwarz, A Meloni… - Neuron, 1995 - cell.com
The gene defective in Huntington's disease encodes a protein, huntingtin, with unknown
function. Antisera generated against three separate regions of huntingtin identified a single …
function. Antisera generated against three separate regions of huntingtin identified a single …
Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways
Huntingtin is a cytoplasmic protein that is found in neurons and somatic cells. In patients with
Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded …
Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded …
Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation
KE De Rooij, JC Dorsman, MA Smoor… - Human molecular …, 1996 - academic.oup.com
Huntington's disease is a progressive neurodegenerative disorder, which is caused by
expansion of a polymorphic (CAG) n repeat in the coding region of the Huntington's disease …
expansion of a polymorphic (CAG) n repeat in the coding region of the Huntington's disease …
Fast transport and retrograde movement of huntingtin and HAP 1 in axons
J Block-Galarza, KO Chase, E Sapp, KT Vaughn… - …, 1997 - journals.lww.com
HUNTINGTIN, the protein product of the Huntington's disease gene, associates with vesicle
membranes and microtubules in neurons. Analysis of axonal transport with a stop-flow …
membranes and microtubules in neurons. Analysis of axonal transport with a stop-flow …
Huntingtin localization in brains of normal and Huntington's disease patients
E Sapp, C Schwarz, K Chase, PG Bhide… - Annals of Neurology …, 1997 - Wiley Online Library
The immunohistochemical localization of huntingtin was examined in the Huntington's
disease (HD) brain with an antibody that recognizes the wild‐type and mutant proteins …
disease (HD) brain with an antibody that recognizes the wild‐type and mutant proteins …