Although large deletions comprise 65% of the mutations that underlie most cases of
Duchenne and Becker muscular dystrophies, the DNA sequence characteristics of the …

Over 60% of Duchenne and Becker muscular dystrophies are caused by deletions spanning
tens or hundreds of kilobases in the dystrophin gene. The molecular mechanisms …

The genomic organization of most of the human dystrophin gene has not been defined at
single-exon level, owing to its enormous size (2300 kb). By taking advantage of a YAC …

The region of the dystrophin gene containing introns 45–50 is characterized by a high rate of
recombination events that give rise to large deletions causing dystrophinopathy. The …

We have analyzed patient DNA samples in 77 unrelated Duchenne (DMD) and Becker
(BMD) muscular dystrophy families, 73 of which were of French Canadian origin. We show …

The enormous size of the human dystrophin gene (2300 kb) has so far hindered the analysis
of its organization and the characterization at the genomic level of the deletion and …

Large intragenic deletions within the DMD locus account for about 60% of Duchenne and
Becker muscular dystrophy patients. Two deletion hot-spots have been described in the …

Although large deletions in the dystrophin gene have been identified in more than two-thirds
of Duchenne and Becker muscular dystrophy patients, the molecular mechanisms that lead …

Duchenne and Becker muscular dystrophies (DMD and BMD) are caused by defects in the
dystrophin gene. About two-thirds of the affected patients have large deletions or …

Exon deletions in the human DMD gene, which encodes the dystrophin protein, are the
molecular defect in 50–70% of cases of Duchenne/Becker muscular dystrophies. Deletions …