Actin polymerization at the cell cortex is thought to provide the driving force for aspects of
cell-shape change and locomotion. To coordinate cellular movements, the initiation of actin …

The assembly of a branched network of actin filaments provides the mechanical propulsion
that drives a range of dynamic cellular processes, including cell motility. The Arp2/3 complex …

Wiskott-Aldrich syndrome protein (WASP) and neural (N)-WASP regulate dynamic actin
structures through the ability of their VCA domains to bind to and stimulate the actin …

In response to signaling, the Arp2/3 complex (actin-related proteins 2 and 3 complex) is
activated by binding the C-terminal (WA) domain of proteins of the Wiskott-Aldrich Syndrome …

In response to upstream signals, proteins in the Wiskott-Aldrich Syndrome protein (WASP)
family regulate actin nucleation via the Arp2/3 complex. Despite intensive study of the …

Actin related protein 2/actin related protein 3 (Arp2/3) complex nucleates new actin filaments
in eukaryotic cells in response to signals from proteins in the Wiskott–Aldrich syndrome …

Proteins of the Wiskott-Aldrich Syndrome protein (WASp) family connect signaling pathways
to the actin polymerization-driven cell motility. The ubiquitous homolog of WASp, N-WASp, is …

We purified native WASp (Wiskott-Aldrich Syndrome protein) from bovine thymus and
studied its ability to stimulate actin nucleation by Arp2/3 complex. WASp alone is inactive in …

Protrusion of lamellipodia and filopodia from the cell surface requires that actin polymerize
locally. Actin polymerization is initiated by numerous agonists, including growth factors …

ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as
nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives …