Retroviruses such as human immunodeficiency virus (HIV) are distinguished from other
viruses by the combination of two steps in the viral life cycle. The first is reverse transcription …

One of the most crucial steps in the life cycle of a retrovirus is the integration of the viral DNA
(vDNA) copy of the RNA genome into the genome of an infected host cell. Integration …

Integration of the retrovirus DNA genome into host chromosomes is essential for viral
replication. After virus infection of the cell, synthesis of viral cDNA occurs by reverse …

Integration into the host-cell genome is a critical step in the retrovirus life cycle. In particular,
the choice of the integration site is crucial for retroviral replication, since integration at a site …

Retroviruses synthesize a double stranded DNA copy of their RNA genome after Infection of
a permissive cell and subsequent integration of this DNA copy into thehost genome is …

The single-stranded genomic RNA of retroviruses is reverse-transcribed to produce double-
stranded linear DNA shortly after entry of the virion into the host cell. For HIV, this reaction …

Retroviral vectors are popular vehicles for gene transfer, since they neatly integrate a single
copy of a new gene into a transduced cell. The viral cDNA that becomes integrated is …

Integration is an essential step in the life cycle of retroviruses, resulting in the stable joining
of the viral cDNA to the host cell chromosomes. While this critical process makes …

To complete their replication cycle, retroviruses need to integrate a DNA copy of their RNA
genome into a host chromosome. Integration site selection is not random and is driven by …

Since integration into the host cell genome is an obligatory step for their replication, retro-
elements are both potent insertional mutagens and also suitable vectors for gene therapy …