The guanosine triphosphatase (GTPase) Rab32 coordinates a cell-intrinsic host defense
mechanism that restricts the replication of intravacuolar pathogens such as Salmonella …

Cell-intrinsic defences constitute the first line of defence against intracellular pathogens. The
guanosine triphosphatase RAB32 orchestrates one such defence response against the …

The bacterial pathogen Legionella pneumophila exploits host cell vesicle transport by
transiently manipulating the activity of the small guanosine triphosphatase (GTPase) Rab1 …

Unlike other Salmonellae, the intracellular bacterial human pathogen Salmonella Typhi
exhibits strict host specificity. The molecular bases for this restriction are unknown. Here we …

Eukaryotic cells can use the autophagy pathway to defend against microbes that gain
access to the cytosol or reside in pathogen-modified vacuoles. It remains unclear if …

Successful elimination of bacteria in phagocytes occurs in the phago-lysosomal system, but
also depends on mitochondrial pathways. Yet, how these two organelle systems …

Cell-autonomous defense mechanisms are potent strategies that protect individual cells
against intracellular pathogens. The Rab-family GTPase Rab32 was previously shown to …

We found that the autophagic machinery could effectively eliminate pathogenic group A
Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the …

Rab guanosine triphosphatases (GTPases) regulate vesicle trafficking in eukaryotic cells by
reversibly associating with lipid membranes. Inactive Rab GTPases are maintained in the …

The pathogenesis of infection is a continuously evolving battle between the human host and
the infecting microbe. The past decade has brought a burst of insights into the molecular …