The dynamics of LH secretion and clearance were studied in vivo in eight healthy young
men using a novel multiple parameter deconvolution procedure to resolve underlying …

The exact nature of glandular secretory events is difficult to discern in vivo, since underlying
patterns of hormone release are confounded by metabolic clearance. Moreover …

To examine the stimulus-secretion response of human pituitary gonadotrophs in vivo, we
applied a new multiple parameter deconvolution technique to analyze (1) exogenous GnRH …

We have appraised the nature of spontaneous luteinizing hormone (LH) secretory events in
normal men by analyzing immunoactive LH concentrations in blood samples withdrawn at 5 …

Deconvolution methods constitute a class of analytic tools to quantitate hormone secretion
and/or clearance in vivo. Although mathematically rigorous, deconvolution techniques have …

The demonstration that luteinizing hormone (LH) release from the pituitary is episodic rather
than constant raises fundamental questions regarding the physiologic control of pulsatile LH …

Testosterone injections or pharmacological amounts of dihydrotestosterone infused in men,
and androgen-secreting tumors in women, can suppress plasma LH bioactivity assessed in …

The episodic nature of gonadotropin secretion was originally defined by RIA of circulating
LH concentrations. We analyzed the pulsatile release of biologically active LH by measuring …

The development of an in vitro bioassay of high specificity, sensitivity and precision for the
measurement of low circulating concentrations of biologically active glycoprotein hormones …

In both men and women the pulsatile secretory pattern of LH has been extensively
characterized. In the present study we used the algorithm for computation of instantaneous …