Elevated blood homocysteine and risk of Alzheimer's Dementia: an updated systematic review and meta-analysis based on prospective studies

M Zuin, C Cervellati, G Brombo, A Trentini… - The Journal of …, 2021 - Springer
Objective To investigate whether high serum homocysteine (Hcy) levels is associated with
the risk of developing Alzheimer's disease (AD) by performing a meta-analysis based on …

Hyperhomocysteinemia and risk of incident cognitive outcomes: an updated dose-response meta-analysis of prospective cohort studies

F Zhou, S Chen - Ageing research reviews, 2019 - Elsevier
Objective This study aimed to comprehensively assess the dose-response relationship
between blood homocysteine levels and risk of all cause, Alzheimer and vascular dementia …

Blood and CSF homocysteine levels in Alzheimer's disease: A meta-analysis and meta-regression of case–control studies

L Zhang, X Xie, Y Sun, F Zhou - Neuropsychiatric Disease and …, 2022 - Taylor & Francis
Objective Hyperhomocysteinemia (HHcy), as an important risk factor for Alzheimer's disease
(AD), would aggravate cognitive dysfunction. This study aimed to investigate whether and to …

Is high homocysteine level a risk factor for cognitive decline in elderly? A systematic review, meta-analysis, and meta-regression

RCM Ho, MWL Cheung, E Fu, HH Win, MH Zaw… - The American Journal of …, 2011 - Elsevier
Obective: High homocysteine (Hct) has been causatively linked to Alzheimer disease (AD)
and vascular dementia (VaD) in old age, but research methodologies and outcome …

Hyperhomocysteinemia and Alzheimer's disease: A systematic review

F Van Dam, WA Van Gool - Archives of gerontology and geriatrics, 2009 - Elsevier
Hyperhomocysteinemia (HHcy) is supposed to be one of the modifiable risk factors that, if
treated, may delay the onset of Alzheimer's disease (AD). The relation between serum …

Homocysteine and folic acid: risk factors for Alzheimer's disease—an updated Meta-analysis

Q Wang, J Zhao, H Chang, X Liu, R Zhu - Frontiers in aging …, 2021 - frontiersin.org
Background: Recent studies have reported that homocysteine (Hcy) may play a vital role in
the pathogenesis of vascular dementia (VaD) and Alzheimer's disease (AD). Our study …

Homocysteine and Alzheimer's disease: evidence for a causal link from Mendelian randomization

Q Hu, W Teng, J Li, F Hao… - Journal of Alzheimer's …, 2016 - content.iospress.com
Background/Objective: The relationship between plasma homocysteine (Hcy) levels and
Alzheimer's disease (AD) has been studied for many years, but remains controversial. While …

Associations between homocysteine, folic acid, vitamin B12 and Alzheimer's disease: insights from meta-analyses

L Shen, HF Ji - Journal of Alzheimer's Disease, 2015 - content.iospress.com
The associations between homocysteine (Hcy), folic acid, and vitamin B12 and Alzheimer's
disease (AD) have gained much interest, while remaining controversial. We aim to perform …

Plasma homocysteine and risk of mild cognitive impairment

C Reitz, MX Tang, J Miller, R Green… - Dementia and geriatric …, 2009 - karger.com
Abstract Background and Objective: There are conflicting data relating homocysteine levels
to the risk of Alzheimer's disease (AD). We sought to explore whether fasting plasma …

[HTML][HTML] Hypohomocysteinemia may increases the risk of dementia and Alzheimer's disease: A nationwide population-based prospective cohort study

JB Bae, JW Han, J Song, K Lee, TH Kim, KP Kwak… - Clinical Nutrition, 2021 - Elsevier
Background Hyperhomocysteinemia has been repeatedly found to increase the risk of
dementia. However, the effects of hypohomocysteinemia on the risk of dementia have been …