We have shown that superoxide anion (O 2−) production by the osteoclast can be used as
an index of the osteoclast activity since the agents that inhibit and stimulate the osteoclast …

Calciotropic hormones such as parathyroid hormone (PTH) and calcitonin have been shown
to have stimulatory and inhibitory effects respectively on superoxide anion (O2) generation …

We have investigated the possible acute effect of steroid hormones, including 1α, 25
dihydroxycholecalciferol (1α, 25 (OH) 2D3) and estradiol, on the generation of superoxide …

The electrochemical determination of superoxide anion generation by isolated mammalian
osteoclasts was carried out by employing cytochrome c, immobilized at a surface‐modified …

The mechanisms by which bone resorbing osteoclasts form and are activated by hormones
are poorly understood. We show here that the generation of oxygen-derived free radicals in …

The molecular mechanisms underlying the pathophysiology of bone destruction still remain
poorly understood. We have found that hydrogen peroxide (H 2 O 2), a reactive oxygen …

Osteoclasts have been shown to destroy calcified tissue by complex developmental steps
involving cell recruitment, cell attachment and deployment of multiple enzymes. They also …

Osteoclasts were isolated on glass or plastic substrates and the effect of bone‐active
hormones and prostaglandins on their behaviour was observed. Untreated osteoclasts …

Objective Parathyroid hormone (PTH) induced bone resorption by osteoclasts depends on
the presence of osteoblasts. PTH induced production of prostaglandins by osteoblasts and …

Prostaglandin Es (PGEs) are known to be stimulators of bone resorption, but there are
conflicting reports as to the effects of PGE2 and synthetic 16, 16-dimethyl-PGE2 on plasma …