The mechanisms by which bone resorbing osteoclasts form and are activated by hormones
are poorly understood. We show here that the generation of oxygen-derived free radicals in …

Oxygen derived free radicals are generated by osteoclasts. In a novel culture system,
isolated rat osteoclasts were stained when nitroblue tetrazolium (NBT) was reduced by …

The molecular mechanisms underlying the pathophysiology of bone destruction still remain
poorly understood. We have found that hydrogen peroxide (H 2 O 2), a reactive oxygen …

Recent reports have suggested that production of superoxide or other reactive oxygen
species by activated osteoclasts may play a role in the complex process of bone resorption; …

Production of superoxide radicals by osteoclasts is necessary for normal bone degradation.
White blood cell superoxide, needed for bacterial killing, is produced by activated NADPH …

Reactive oxygen species such as superoxide and hydrogen peroxide have been implicated
as regulatory factors in the control of osteoclastic bone resorption. While superoxide radicals …

The reaction of superoxide with nitroblue tetrazolium produces an electron-dense
diformazan precipitate which can be used to localize areas of superoxide production …

In the present paper, the involvement of active oxygen species in bone resorption has been
studied. In order to compare the production of active oxygen by mouse marrow culture cells …

Hypoxia is known to act as a general stimulator of cells derived from marrow precursors. We
investigated the effect of oxygen tension on the formation and function of osteoclasts, the …

Osteoclasts have been shown to produce reactive oxygen intermediates (ROI) and it has
been suggested that ROI are involved in the process of bone resorption. ROI have also been …