Background: Perinatal asphyxia, leading to neonatal encephalopathy, is one of the leading
causes for child mortality and long-term morbidities. Neonatal encephalopathy rates are …

Hypoxic‐ischemic encephalopathy (HIE) mainly affects preterm and term newborns, leading
to a high risk of brain damage. Coexisting infection/inflammation and birth asphyxia are key …

Background Neonatal encephalopathy due to hypoxia–ischemia (HI) is a leading cause of
death and disability in term newborns. Therapeutic hypothermia (HT) is the only …

In the present study, we tested whether the ongoing differentiation of microglia in the
immature brain results in more robust microglial activation and pro-inflammatory responses …

Background: Microglia are key mediators of inflammation during perinatal brain injury. As
shown experimentally after inflammation-sensitized hypoxic ischemic (HI) brain injury …

Neonatal hypoxic–ischemic (H‐I) injury, which mainly causes neuronal damage and white
matter injury (WMI), is among the predominant causes of infant morbidity (cerebral palsy …

We previously found increased microglial proliferation and pro-inflammatory cytokine
release in infant mice compared to juvenile mice after hypoxia–ischemia (HI). The aim of the …

Background Neuroinflammation plays an important role in neonatal hypoxic-ischemic
encephalopathy (HIE). Although microglia are largely responsible for injury-induced …

The mechanisms of neuronal injury after hypoxia–ischemia (HI) are different in the immature
and the adult brain, but microglia activation has not been compared. The purpose of this …

Hypoxic-ischemic (HI) injury to developing brain results from birth asphyxia in neonates and
from cardiac arrest in infants and children. It is associated with varying degrees of neurologic …