Reactive oxygen species such as superoxide and hydrogen peroxide have been implicated
as regulatory factors in the control of osteoclastic bone resorption. While superoxide radicals …

The molecular mechanisms underlying the pathophysiology of bone destruction still remain
poorly understood. We have found that hydrogen peroxide (H 2 O 2), a reactive oxygen …

The mechanisms by which bone resorbing osteoclasts form and are activated by hormones
are poorly understood. We show here that the generation of oxygen-derived free radicals in …

Abstract Hydrogen peroxide (H 2 O 2), superoxide anion radical (O 2− radical dot), and other
forms of reactive oxygen species (ROS) are produced by the vast majority of mammalian …

Effects of h2o2 on bone were evaluated in an organ culture system. Tibiae from chick
embryos were incubated for up to 3 days in culture medium containing 0.07 to 20 mM H2O2 …

Oxygen derived free radicals are generated by osteoclasts. In a novel culture system,
isolated rat osteoclasts were stained when nitroblue tetrazolium (NBT) was reduced by …

In the present paper, the involvement of active oxygen species in bone resorption has been
studied. In order to compare the production of active oxygen by mouse marrow culture cells …

Hypoxia is known to act as a general stimulator of cells derived from marrow precursors. We
investigated the effect of oxygen tension on the formation and function of osteoclasts, the …

Production of superoxide radicals by osteoclasts is necessary for normal bone degradation.
White blood cell superoxide, needed for bacterial killing, is produced by activated NADPH …

Abstract Hydrogen peroxide (H 2 O 2), an oxidizing agent, has been widely used as a
disinfectant. Recently, because of its reactive properties, H 2 O 2 has also been used as a …