Macromolecular machines carry out many cellular functions. Cryo-electron microscopy (cryo-
EM) is emerging as a powerful method for studying the structure, assembly and dynamics of …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

Structural biology is going through a revolution as a result of transformational advances in
the field of cryo-electron microscopy (cryo-EM) driven by the development of direct electron …

Cryo‐electron microscopy (cryo‐EM) is increasingly becoming a mainstream technology for
studying the architecture of cells, viruses and protein assemblies at molecular resolution …

Cryo-electron microscopy (cryo-EM) is a structural molecular and cellular biology technique
that has experienced major advances in recent years. Technological developments in image …

For many years, structure determination of biological macromolecules by cryo-electron
microscopy (cryo-EM) was limited to large complexes or low-resolution models. With recent …

Over the past several years, single-particle cryo-electron microscopy (cryo-EM) has
emerged as a leading method for elucidating macromolecular structures at near-atomic …

Single particle cryo-EM has recently developed into a powerful tool to determine the 3D
structure of macromolecular complexes at near-atomic resolution, which allows structural …

Electron cryomicroscopy (cryo-EM) has established itself as a powerful tool for the study of
the structure and function of biological macromolecules. Resolutions of∼ 4–5 Å for single …

Background Since the introduction of what became today's standard for cryo-embedding of
biological macromolecules at native conditions more than 30 years ago, techniques and …