Novel pyrone side tetracyclic psoralen derivatives: synthesis and photobiological evaluation

L Dalla Via, E Uriarte, E Quezada… - Journal of medicinal …, 2003 - ACS Publications
This study reports the synthesis of tetrahydrobenzo-(4− 6) and benzopsoralen (7− 9)
derivatives obtained by condensing the fourth ring to the pyrone side of the tricyclic psoralen …

[PDF][PDF] Methyl derivatives of tetracyclic psoralen analogues: antiproliferative activity and interaction with DNA

L Dalla Via, E Uriarte, L Santana, SM Magno, O Gia - 2004 - arkat-usa.org
A number of new tetracyclic psoralen derivatives were studied. The fourth ring is constituted
by cyclopentane (4, 7 and 9), cyclohexane (11, 15 and 18) or benzene (12, 16 and 20) fused …

Design, synthesis and photobiological properties of 3, 4-cyclopentenepsoralens

O Gia, SM Magno, H Gonzalez-Diaz, E Quezada… - Bioorganic & medicinal …, 2005 - Elsevier
The QSAR directed synthesis of tetracyclic psoralen derivatives (3–5) characterised by the
condensation of a cyclopentane ring at the level of the 3, 4 double bond of the tricyclic …

A new psoralen derivative with enlarged antiproliferative properties

L Dalla Via, JC González-Gómez… - Bioorganic & medicinal …, 2009 - Elsevier
Following our results with benzopsoralens as potent photochemotherapeutic agents, we
report the antiproliferative evaluation of nitrogenated isoster upon and without UVA …

Photobiological studies of new cyclopentene–psoralens

L Dalla Via, O Gia, G Viola, G Bertoloni, L Santana… - Il Farmaco, 1998 - Elsevier
Psoralen analogues bearing a cyclopentane ring fused to either the 4′, 5′ double bond
(compound 4) or the 3, 4 double bond (compound 7) of the tricyclic furocoumarin structure …

Synthesis and photobiological properties of 4‐hydroxymethyl‐4′‐methylpsoralen derivatives

G Zagotto, O Gia, F Baccichetti… - Photochemistry and …, 1993 - Wiley Online Library
The synthesis and the photobiological activity of two new hydroxymethyl derivatives of
psoralen namely 4‐hydroxymethyl‐4′‐methyl‐and 4‐hydroxymethyl‐4′‐methyl‐8 …

New furan side tetracyclic allopsoralen derivatives: synthesis and photobiological evaluation

L Dalla Via, S Mammi, E Uriarte… - Journal of medicinal …, 2006 - ACS Publications
Novel tetracyclic allopsoralen derivatives characterized by the condensation of a fourth
cyclohexenylic (5− 7) or benzenic (8− 10) ring at the furan side and a methoxy (5 and 8), a …

Synthesis and photobiological activity of new methylpsoralen derivatives

O Gia, E Uriarte, G Zagotto, F Baccichetti… - … of Photochemistry and …, 1992 - Elsevier
The synthesis and the photobiological activity of two new derivatives of psoralen (3, 4′-
dimethylpsoralen and 3, 4′, 8-trimethylpsoralen) has been described. They are congeners …

New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: synthesis, DNA interaction, and antiproliferative activity

L Dalla Via, O Gia, S Marciani Magno… - Journal of medicinal …, 1999 - ACS Publications
The synthesis of new tetrahydrobenzo-and benzopsoralen derivatives carrying at position 5
or 8 of the furocoumarin moiety a methoxy, hydroxy, or dimethylaminopropoxy side chain is …

Synthesis, photobiological activity and photoreactivity of methyl-thieno-8-azacoumarins, novel bioisosters of psoralen

L Dalla Via, SM Magno, P Rodighiero, O Gia - Bioorganic & medicinal …, 2002 - Elsevier
4, 4′-dimethyl-thieno-8-azacoumarin (6) and 4, 4′, 5′-trimethyl-thieno-8-azacoumarin (8)
were synthesised. Their photobiological activity was tested on human tumour cell lines …