The assembly of a branched network of actin filaments provides the mechanical propulsion
that drives a range of dynamic cellular processes, including cell motility. The Arp2/3 complex …

THE actin cytoskeleton of a eukaryotic cell is central to locomotion, phagocytosis,
contractility, shape changes, cytokinesis and maintenance of polarity. The mechanisms …

Actin related protein 2/actin related protein 3 (Arp2/3) complex nucleates new actin filaments
in eukaryotic cells in response to signals from proteins in the Wiskott–Aldrich syndrome …

Actin polymerization at the cell cortex is thought to provide the driving force for aspects of
cell-shape change and locomotion. To coordinate cellular movements, the initiation of actin …

In response to signaling, the Arp2/3 complex (actin-related proteins 2 and 3 complex) is
activated by binding the C-terminal (WA) domain of proteins of the Wiskott-Aldrich Syndrome …

Summary Members of the Wiskott-Aldrich syndrome protein (WASP) family control actin
dynamics in eukaryotic cells by stimulating the actin nucleating activity of the Arp2/3 …

The actin-related protein 2/3 (Arp2/3) complex is the primary nucleator of new actin filaments
in most crawling cells. Nucleation-promoting factors (NPFs) of the Wiskott-Aldrich syndrome …

The proteins of the Wiskott-Aldrich syndrome protein (WASP) family are activators of the
ubiquitous actin nucleation factor, the Arp2/3 complex. WASP family proteins contain a C …

Actin nucleation and branching by the Arp2/3 complex is tightly regulated by activating
factors. However, the mechanism of Arp2/3 complex activation remains unclear. We used …

ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as
nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives …