SARS-CoV-2 nonstructural protein 3 (Nsp3) contains a macrodomain that is essential for
coronavirus pathogenesis and is thus an attractive target for drug development. This …

PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular
pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within
the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate …

ABSTRACT ADP-ribosylation is a common posttranslational modification that may have
antiviral properties and impact innate immunity. To regulate this activity, macrodomain …

Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-
translational modification implicated in the creation of an antiviral environment via immune …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other SARS-related
CoVs encode 3 tandem macrodomains within nonstructural protein 3 (nsp3). The first …

SARS-CoV-2, the causative agent of COVID-19 encodes at least 16 nonstructural proteins of
variably understood function. Nsp3, the largest nonstructural protein contains several …

The virus that causes COVID-19, SARS-CoV-2, has a large RNA genome that encodes
numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as …

Abstract SARS-CoV-2 nsp3 is essential for viral replication and host responses. The SARS-
unique domain (SUD) of nsp3 exerts its function through binding to viral and host proteins …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic. While previous studies have …