Metastasis to bones is determined by both intrinsic traits of metastatic tumor cells and
properties appertaining to the bone microenvironment. Bone marrow niches are critical for …

Bone metastasis, or the development of secondary tumors within the bone of cancer
patients, is a debilitating and incurable disease. Despite its morbidity, the biology of bone …

Bone marrow is a heterogeneous organ containing diverse cell types, and it is a preferred
metastatic site for several solid tumors such as breast and prostate cancer. Recently, it has …

Breast cancer bone metastasis develops as the result of a series of complex interactions
between tumor cells, bone marrow cells, and resident bone cells. The net effect of these …

The bone marrow has been long known to host a unique environment amenable to
colonization by metastasizing tumor cells. Yet, the underlying molecular interactions within …

Advanced cancers are prone to metastasize. Visceral metastases are more likely to be fatal,
while patients with only metastases to bone can survive up to 10 years or more. However …

Many solid cancers metastasize to the bone and bone marrow (BM). This process may occur
even before the diagnosis of primary tumors, as evidenced by the discovery of disseminated …

The bone marrow has been widely recognised to host a unique microenvironment that
facilitates tumour colonisation. Bone metastasis frequently occurs in the late stages of …

The skeleton is a common destination for many cancer metastases including breast and
prostate cancer. There are many characteristics of bone that make it an ideal environment …

Bone metastases are a frequent and severe complication of advanced-stage cancers. Breast
and prostate cancers, the most common malignancies in women and men, respectively …