Noncovalent interactions between aromatic molecules are widely believed to be important
contributing factors in the stabilization of organized structure in biological macromolecules …

Noncovalent interactions between aromatic nucleobases are the major stabilizing forces
which contribute to the structural integrity of duplex DNA and RNA. 1–3 However, base …

We report the properties of hydrophobic isosteres of pyrimidines and purines in synthetic
DNA duplexes. Phenyl nucleosides 1 and 2 are nonpolar isosteres of the natural thymidine …

We report the use of thermodynamic measurements in a self-complementary DNA duplex (5
'-dXCGCGCG) 2, where X is an unpaired natural or nonnatural deoxynucleoside, to study …

The synthesis of a series of 2′-deoxyuridine analogues modified at the 5-position and a
series of 2′-deoxypurines modified at the 8-position is described. Ultraviolet melting …

We address the recent debate surrounding the ability of 2, 4-difluorotoluene (F), a low-
polarity mimic of thymine (T), to form a hydrogen-bonded complex with adenine in DNA. The …

We describe the properties in DNA of a set of five nonpolar nucleoside mimics in which
shape is similar but size is increased gradually. The compounds vary in the size of their …

Due to their selective complementary base-association phenomena and their enhanced
resistance against enzymatic degradation, DNA analogs attract considerable attention as …

Aromatic systems contain both σ-and π-electrons, which in turn constitute σ-and π-molecular
orbitals (MOs). In discussing the properties of these systems, researchers typically refer to …

The polymorphic nature of double-stranded DNA is well established. 1 A common feature of
three major families of A-, B-, and Z-DNA duplexes is the antiparallel orientation of the …