Esophageal squamous cell carcinoma (ESCC) has a very high incidence rate in
northeastern Iran. Our team previously reported the BReast CAncer gene 2 (BRCA2) p …

PURPOSE The BRCA2 p. K3326* variant is considered a low-penetrance variant for breast
cancer. Aldehydes that accumulate in cells under insufficient aldehyde oxidation were most …

AIM: To investigate the role of metabolic enzyme and DNA repair genes in susceptibility of
esophageal squamous cell carcinoma (ESCC). METHODS: A case-control study was …

Background Esophageal cancer (EC) is the sixth leading cause of cancer-associated death
worldwide. The interaction of environmental risk factors and genetic factors might contribute …

Objective: A meta-analysis was carried out to further evaluate the relationship between
ALDH2 Glu487Lys polymorphism and esophageal cancer risk. Methods: A total number of …

Background Aldehyde dehydrogenase 2 (ALDH2), a critical enzyme for the detoxification of
alcohol, is associated with many types of cancers. To verify the relationship of ALDH2 rs671 …

Objective Genetic polymorphisms in ALDH 2 and C12orf30 genes have been reported to
increase the risk of developing esophageal squamous cell carcinoma (ESCC). This study …

Background The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys
polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This …

Abstract<? Pub Inc> Esophageal squamous cell carcinoma (ESCC) is a common cancer in
the northeast of Iran. In a series of studies we explored the genetic basis for this. First we …

Background Alcohol consumption is a major risk factor for esophageal cancer; however, a
high incidence of esophageal cancer is observed particularly among Eastern Asians …