Human colony-forming units-erythroid do not require accessory cells, but do require direct interaction with insulin-like growth factor I and/or insulin for erythroid …

K Sawada, SB Krantz, EN Dessypris… - The Journal of …, 1989 - Am Soc Clin Investig
The presence of heterogeneous erythroid progenitor cells, contaminant cells, or serum may
alter erythroid colony development in vitro. To obtain highly purified colony-forming units …

Purification of human erythroid colony-forming units and demonstration of specific binding of erythropoietin.

K Sawada, SB Krantz, JS Kans… - The Journal of …, 1987 - Am Soc Clin Investig
Morphological and biochemical studies of human colony-forming units-erythroid (CFU-E)
have been hindered by their extreme rarity. Since burst-forming units-erythroid (BFU-E) …

Pure erythropoietic colony and burst formations in serum-free culture and their enhancement by insulin-like growth factor I.

K Akahane, A Tojo, A Urabe, F Takaku - Experimental hematology, 1987 - europepmc.org
Recombinant human insulin-like growth factor I (IGF-I) increased human and murine
erythropoietic colony formation in serum-free culture. In order to investigate the effects of …

Roles of erythropoietin, insulin-like growth factor 1, and unidentified serum factors in promoting maturation of purified murine erythroid colony-forming units

SH Boyer, TR Bishop, OC Rogers, AN Noyes, LP Frelin… - 1992 - ashpublications.org
Abstract We have used 75% to 90% pure murine erythroid colony-forming units (CFU-E) to
delineate the processes and factors underlying their maturation. These CFU-E form 32 cell …

Distinct roles of erythropoietin, insulin-like growth factor I, and stem cell factor in the development of erythroid progenitor cells.

K Muta, SB Krantz, MC Bondurant… - The Journal of clinical …, 1994 - Am Soc Clin Investig
Erythropoietin (EP), insulin-like growth factor I (IGF-I) and stem cell factor (SCF) each reduce
apoptosis of human erythroid progenitor cells. To determine if these growth factors have …

Characterization of an erythroid precursor cell of high proliferative capacity in normal human peripheral blood.

BJ Clarke, D Housman - Proceedings of the National …, 1977 - National Acad Sciences
We have found that the peripheral blood of normal humans contains a significant number of
committed erythroid stem cells of high proliferative capacity. These erythroid stem cells …

Insulin stimulates erythroid colony formation independently of erythropoietin

A Kurtz, W Jelkmann, C Bauer - British journal of haematology, 1983 - Wiley Online Library
The effect of insulin on the proliferation of late stage erythroid precursor cells (CFU‐e) from
fetal mouse liver and aduit bone marrow was studied in a serum‐free culture system. Insulin …

A new candidate for the regulation of erythropoiesis: Insulin‐like growth factor I

A Kurtz, W Jelkmann, C Bauer - FEBS letters, 1982 - Wiley Online Library
The effect of pure human insulin‐like growth factor I (IGF I) on the colony formation of late
stage erythroid precursor cells (CFU‐e) from fetal mouse liver and adult bone marrow was …

Production of erythropoietic bursts by progenitor cells from adult human peripheral blood in an improved serum-free medium: role of insulinlike growth factor 1

PN Correa, AA Axelrad - 1991 - ashpublications.org
Several culture media for the growth of human circulating erythroid burst-forming units (BFU-
E) that have been claimed to be “serum-free”(“SF”) have actually included albumin …

Erythropoietin alone induces erythroid burst formation by human embryonic but not adult BFU-E in unicellular serum-free culture [see comments]

M Valtieri, M Gabbianelli, E Pelosi, E Bassano, S Petti… - 1989 - ashpublications.org
Erythroid progenitors (BFU-E) from adult human peripheral blood generate erythroid bursts
in semisolid culture supplemented with at least two growth factors, ie, erythropoietin (Ep) …