Background The endogenous tissue inhibitor of metalloproteinase-2 (TIMP-2), through its
homeostatic action on certain metalloproteinases, plays a vital role in remodelling …

Background The metzincin family of metalloproteinases and the tissue inhibitors of
metalloproteinases (TIMPs) are essential proteins required for biological processes during …

Tissue inhibitor of metalloproteinases-3 (TIMP3) is vital in regulating several biological
processes. TIMP3 exerts antitumour effects via matrix metalloproteinase (MMP)-dependent …

Tissue inhibitor of metalloproteinase‐4 (TIMP‐4) belongs to a family of extracellular matrix
(ECM) metalloproteinases inhibitors that are overexpressed in several cancers. However …

Remodeling of the extracellular matrix (ECM) to facilitate invasion and metastasis is a
universal hallmark of cancer progression. However, a definitive therapeutic target remains to …

Tissue inhibitors of metalloproteinases (TIMPs) play key roles in maintaining homeostasis of
the extracellular matrix by controlling matrix metalloproteinases (MMPs). In addition to their …

Matrix metalloproteinases and their natural inhibitors (TIMPs) are important elements in a
wide range of oncology settings. Elevated levels of tissue inhibitor of metalloproteinase-1 …

Background: TIMP3 is a multifunctional proteolytic enzyme belonging to TIMPs family and
acts as a potent inhibitor of matrix metalloproteinases (MMPs). TIMP3 possesses a tumor …

Treatment options for late stage prostate and colon cancer are limited and there is an urgent
need to develop more effective and targeted novel therapies, which starts with identification …

Epithelial Ovarian Cancer (EOC) is the most lethal gynecological cancer in developed
countries, and the development of new strategies to overcome chemoresistance is an …