A method of in situ hybridization for visualizing individual human chromosomes from pter to
qter, both in metaphase spreads and interphase nuclei, is reported. DNA inserts from a …

The position and arrangement of individual chromosomes in interphase nuclei were
examined in mouse-human cell hybrids by in situ hybridization of biotinylated human DNA …

Chromosome territories need to be well defined at high resolution before functional aspects
of chromosome organization in interphase can be explored. To visualize chromosomes by …

A new approach is presented which allows the in vivo visualization of individual
chromosome territories in the nuclei of living human cells. The fluorescent thymidine analog …

Summary In spite of Carl Rabl's (1885) and Theodor Boveri's (1909) early hypothesis that
chromosomes occupy discrete territories or domains within the interphase nucleus …

Chromosome aberrations in two glioma cell lines were analyzed using biotinylated DNA
library probes that specifically decorate chromosomes 1, 4, 7, 18 and 22 from pter to qter …

Double in situ hybridization with mercurated and biotinylated chromosome specific DNA
probes in combination with digital image analysis provides a new approach to compare the …

Human karyotype is usually studied by classical cytogenetic (banding) techniques. To
perform it, one has to obtain metaphase chromosomes of mitotic cells. This leads to the …

Chromosomes can be specifically stained in metaphase spreads and interphase nuclei by in
situ hybridization with entire chromosome-specific DNA libraries. Unlabeled human genomic …

Human-rodent hybrid cell lines have been analyzed with regard to their human DNA content
by using various DNA probe sets, derived from the hybrids, for in situ hybridization to normal …