The role of the septin family in spermiogenesis

YH Lin, YC Kuo, HS Chiang, PL Kuo - Spermatogenesis, 2011 - Taylor & Francis
Septins (full name: Septin; symbol name: SEPT) belong to a family of polymerizing GTP
binding proteins that are required for many cellular functions, including membrane …

The expression level of septin12 is critical for spermiogenesis

YH Lin, YM Lin, YY Wang, IS Yu, YW Lin… - The American journal of …, 2009 - Elsevier
Septins belong to a family of polymerizing GTP-binding proteins that are required for many
cellular functions, such as membrane compartmentalization, vesicular trafficking, mitosis …

SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility

YR Shen, HY Wang, YC Kuo, SC Shih, CH Hsu… - PLoS …, 2017 - journals.plos.org
Septins are critical for numerous cellular processes through the formation of heteromeric
filaments and rings indicating the importance of structural regulators in septin assembly …

Regulation of septin phosphorylation: SEPT12 phosphorylation in sperm septin assembly

CH Lin, YR Shen, HY Wang, CW Chiang… - …, 2019 - Wiley Online Library
The sperm annulus, a septin‐based ring structure, is important for reproductive physiology. It
is composed of SEPT12‐based septin core complex followed by assembling as octameric …

Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa

M Ihara, A Kinoshita, S Yamada, H Tanaka… - Developmental cell, 2005 - cell.com
Septins are polymerizing GTP binding proteins required for cortical organization during
cytokinesis and other cellular processes. A mammalian septin gene Sept4 is expressed …

SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins

YC Kuo, YR Shen, HI Chen, YH Lin… - Journal of cell …, 2015 - journals.biologists.com
Male infertility has become a worldwide health problem, but the etiologies of most cases are
still unknown. SEPT12, a GTP-binding protein, is involved in male fertility. Two SEPT12 …

SEPT12 mutations cause male infertility with defective sperm annulus

YC Kuo, YH Lin, HI Chen, YY Wang, YW Chiou… - Human …, 2012 - Wiley Online Library
Septins are members of the GTPase superfamily, which has been implicated in diverse
cellular functions including cytokinesis and morphogenesis. Septin 12 (SEPT12) is a testis …

[HTML][HTML] SEPT12-microtubule complexes are required for sperm head and tail formation

PL Kuo, HS Chiang, YY Wang, YC Kuo… - International journal of …, 2013 - mdpi.com
The septin gene belongs to a highly conserved family of polymerizing GTP-binding
cytoskeletal proteins. SEPTs perform cytoskeletal remodeling, cell polarity, mitosis, and …

CDC42 negatively regulates testis-specific SEPT12 polymerization

CY Huang, YY Wang, YL Chen, MF Chen… - International journal of …, 2018 - mdpi.com
Septin (SEPT) genes encode well-preserved polymerizing GTP-binding cytoskeletal
proteins. The cellular functions of SEPTs consist of mitosis, cytoskeletal remodeling, cell …

Testis-specific SEPT12 expression affects SUN protein localization and is involved in mammalian spermiogenesis

CH Yeh, YY Wang, SK Wee, MF Chen… - International journal of …, 2019 - mdpi.com
Male infertility is observed in approximately 50% of all couples with infertility.
Intracytoplasmic sperm injection (ICSI), a conventional artificial reproductive technique for …