The molecular mechanism underlying the selective vulnerability of certain neuronal
populations associated with neurodegenerative diseases remains poorly understood. Basal …

Autophagy activity is essential for the survival of neural cells. Impairment of autophagy has
been implicated in the pathogenesis of neurodegenerative disorders. Unlike the massive …

Although macroautophagy deficits are implicated across adult-onset neurodegenerative
diseases, we understand little about how the discrete, highly evolved cell types of the central …

Synapses are critical for neuronal communication and brain function. To maintain neuronal
homeostasis, synapses rely on autophagy. Autophagic alterations cause neurodegeneration …

Neurons are highly polarized and post-mitotic cells with the specific requirements of
neurotransmission accompanied by high metabolic demands that create a unique challenge …

Autophagy is a cellular digestion process that contributes to cellular homeostasis and
adaptation by the elimination of proteins and damaged organelles. Evidence suggests that …

Autophagy is a regulated lysosomal degradation process that involves autophagosome
formation and transport. Although recent evidence indicates that basal levels of autophagy …

Mutations in the macroautophagy/autophagy gene WDR45 cause β-propeller protein-
associated neurodegeneration (BPAN); however the molecular and cellular mechanism of …

Autophagy has recently emerged as potential drug target for prevention of
neurodegeneration. However, the details of the autophagy process and regulation in the …

Autophagy, a regulated cellular degradation process responsible for the turnover of long-
lived proteins and organelles, has been increasingly implicated in neurological disorders …