Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry

TB Bigdeli, G Genovese, P Georgakopoulos… - Molecular …, 2020 - nature.com
Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting
tens of millions of individuals worldwide. While rare genetic variants play a role in the …

Comparative genetic architectures of schizophrenia in East Asian and European populations

M Lam, CY Chen, Z Li, AR Martin, J Bryois, X Ma… - Nature …, 2019 - nature.com
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …

Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia

D Curtis - Psychiatric genetics, 2018 - journals.lww.com
Background The polygenic risk score (PRS) for schizophrenia, derived from very large
numbers of weakly associated genetic markers, has been repeatedly shown to be robustly …

Genome‐wide association study of schizophrenia in Ashkenazi Jews

FS Goes, J McGrath, D Avramopoulos… - American Journal of …, 2015 - Wiley Online Library
Schizophrenia is a common, clinically heterogeneous disorder associated with lifelong
morbidity and early mortality. Several genetic variants associated with schizophrenia have …

Genome‐wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness

TB Bigdeli, S Ripke, SA Bacanu, SH Lee… - American Journal of …, 2016 - Wiley Online Library
Genome‐wide association studies (GWAS) of schizophrenia have yielded more than 100
common susceptibility variants, and strongly support a substantial polygenic contribution of …

Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia

MJ Owen, N Craddock… - Archives of general …, 2010 - jamanetwork.com
This article reviews recent genome-wide association studies (GWAS) of schizophrenia and
considers future research directions. Until recently, genome-wide scans for dis-ease risk …

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …

The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare …

BJ Mowry, J Gratten - Molecular psychiatry, 2013 - nature.com
After decades of halting progress, recent large genome-wide association studies (GWAS)
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …

Genome-wide association study of multiplex schizophrenia pedigrees

DF Levinson, J Shi, K Wang, S Oh… - American Journal of …, 2012 - Am Psychiatric Assoc
Objective The authors used a genome-wide association study (GWAS) of multiply affected
families to investigate the association of schizophrenia to common single-nucleotide …

[PDF][PDF] Additive genetic variation in schizophrenia risk is shared by populations of African and European descent

TR De Candia, SH Lee, J Yang, BL Browning… - The American Journal of …, 2013 - cell.com
To investigate the extent to which the proportion of schizophrenia's additive genetic variation
tagged by SNPs is shared by populations of European and African descent, we analyzed the …