Inhibition of ASCT2-mediated glutamine uptake blocks prostate cancer growth | QUT ePrints
Queensland University of Technology, Brisbane Australia QUT Home Contact A university for the …

Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen
source for macromolecule production, as well as for anaplerotic reactions fuelling the …

In our study, we stated that SLC1A4 was a glutamine transporter. We acknowledge that this
has never been directly shown. To that end, the first articles describing SLC1A4 (ASCT1) …

Despite the known importance of androgen receptor (AR) signaling in prostate cancer, the
processes downstream of AR that drive disease development and progression remain …

Alanine-serine-cysteine transporter 2 (ASCT2) has been associated with increased levels of
metabolism in various malignant tumors. However, its biological significance in the …

Understanding and targeting the metabolic requirements of cancer cells has become a
major focus of cancer researchers and pharmaceutical companies worldwide. There are a …

Glutamine is a conditionally essential amino acid important for cancer cell proliferation
through intermediary metabolism leading to de novo synthesis of purine and pyrimidine …

Cancer cells are metabolically reprogrammed to support their high rates of proliferation,
continuous growth, survival, invasion, metastasis, and resistance to cancer treatments …

Simple Summary Radiation is the standard of care for prostate cancer, but almost half the
patients develop resistant disease. It is imperative to understand the reasons behind …

Simple Summary Glutamine (Gln) plays a critical role in the development and progression of
prostate cancer (PCa). Non-malignant prostate cells are not addicted to Gln, but PCa cells …