The differential regulation of immunoactive FSH and LH secretion by endogenous GnRH
was studied using a GnRH antagonist,[Ac-D2Nal1, d4FPhe2, dTrp3, dArg6] GnRH (the NAL …

To examine the differential regulation of glycoprotein hormone secretion from the
gonadotrope by GnRH, the Nal-Glu GnRH antagonist was administered to euthyroid women …

Two forms of GnRH (GnRH-I and GnRH-II) are expressed in the hypothalamus of humans
and rhesus monkeys, but their relative abilities to stimulate LH and FSH release are …

GnRH antagonists, unlike GnRH agonists, do not act via “'downregulation.” Instead, GnRH
antagonists monopolize the GnRH receptors to such an extent that endogenous GnRH is …

Because of some indication that FSH secretion is less dependent than LH secretion on
GnRH in vivo, we performed experiments to examine the effects of a GnRH antagonist …

To assess its gonadotropin-inhibiting potency in man, three different doses of a GnRH
antagonist ([Ac-D2-Nal1, d4-Cl-Phe2, d3-Pal3, Arg5, d4-p-methoxybenzoyl-2-amino butyric …

The effects of increasing the frequency of pulsatile GnRH administration on LH and FSH
responsiveness were studied in five GnRH-deficient men who had achieved normal sex …

The dose-response effects of a single administration of Nal-Lys-GnRHant (antagonist) on
serum LH and FSH concentrations were compared to the effects of Nal-Glu-GnRHant in …

The inhibitory effect of a GnRH antagonist,[AC-Δ2-Pro1, pFd-Phe2, d-Trp36] GnRH (4F-
Antag), on gonadotropin secretion was determined by four sequential studies in five …

Synthetic long-acting agonistic analogs of GnRH both stimulate and paradoxically inhibit
gonadotropin secretion in male animals and humans. To characterize the stimulatory and …