Production of superoxide radicals by osteoclasts is necessary for normal bone degradation.
White blood cell superoxide, needed for bacterial killing, is produced by activated NADPH …

Osteoclasts use a variety of chemical agents to degrade bone. One important component of
this process is the generation of superoxide. It has been reported that nicotinamide adenine …

Recent reports have suggested that production of superoxide or other reactive oxygen
species by activated osteoclasts may play a role in the complex process of bone resorption; …

Superoxide production contributes to osteoclastic bone resorption. Evidence strongly
indicates that NADPH oxidase is an enzyme system responsible for superoxide generation …

The mechanisms by which bone resorbing osteoclasts form and are activated by hormones
are poorly understood. We show here that the generation of oxygen-derived free radicals in …

Osteoclasts have been shown to destroy calcified tissue by complex developmental steps
involving cell recruitment, cell attachment and deployment of multiple enzymes. They also …

Oxygen‐derived free radicals are produced by osteoclasts. Oxygen radical formation occurs
at the osteoclast/bone surface interface. This location next to bone implies that oxygen …

Oxygen derived free radicals are generated by osteoclasts. In a novel culture system,
isolated rat osteoclasts were stained when nitroblue tetrazolium (NBT) was reduced by …

The molecular mechanisms underlying the pathophysiology of bone destruction still remain
poorly understood. We have found that hydrogen peroxide (H 2 O 2), a reactive oxygen …

Calciotropic hormones such as parathyroid hormone (PTH) and calcitonin have been shown
to have stimulatory and inhibitory effects respectively on superoxide anion (O2) generation …