Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with β-tubulin: relevance to Huntington's disease
Huntington's disease results from an expansion of a series of glutamine repeats in the
protein huntingtin. We have discovered from immunopurification studies that huntingtin …
protein huntingtin. We have discovered from immunopurification studies that huntingtin …
Huntington's disease gene product, huntingtin, associates with microtubules in vitro
T Tukamoto, N Nukina, K Ide, I Kanazawa - Molecular brain research, 1997 - Elsevier
The gene responsible for Huntington's disease produces a large protein with a molecular
weight of≈ 350 k, designated huntingtin. Here, we report that the protein can associate in …
weight of≈ 350 k, designated huntingtin. Here, we report that the protein can associate in …
Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies.
The Huntington disease (HD) phenotype is associated with expansion of a trinucleotide
repeat in the IT15 gene, which is predicted to encode a 348-kDa protein named huntington …
repeat in the IT15 gene, which is predicted to encode a 348-kDa protein named huntington …
Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats
SH Li, XJ Li - Human molecular genetics, 1998 - academic.oup.com
Huntington's disease (HD) is caused by expansion of a glutamine repeat in huntingtin.
Mutant huntingtin contains 36–55 repeats in adult HD patients and> 60 repeats in juvenile …
Mutant huntingtin contains 36–55 repeats in adult HD patients and> 60 repeats in juvenile …
Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation
KE De Rooij, JC Dorsman, MA Smoor… - Human molecular …, 1996 - academic.oup.com
Huntington's disease is a progressive neurodegenerative disorder, which is caused by
expansion of a polymorphic (CAG) n repeat in the coding region of the Huntington's disease …
expansion of a polymorphic (CAG) n repeat in the coding region of the Huntington's disease …
A cellular model that recapitulates major pathogenic steps of Huntington's disease
A Lunkes, JL Mandel - Human molecular genetics, 1998 - academic.oup.com
To gain insight into the pathogenic mechanisms of Huntington's disease (HD), we have
developed a stable cellular model, using a neuroblastoma cell line in which the expression …
developed a stable cellular model, using a neuroblastoma cell line in which the expression …
Molecular aspects of Huntington's disease
HW Walling, JJ Baldassare… - Journal of neuroscience …, 1998 - Wiley Online Library
Huntington's disease (HD) is a progressive neurodegenerative disease striking principally
medium spiny GABAergic neurons of the caudate nucleus of the basal ganglia. It affects …
medium spiny GABAergic neurons of the caudate nucleus of the basal ganglia. It affects …
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
M DiFiglia, E Sapp, K Chase, C Schwarz, A Meloni… - Neuron, 1995 - cell.com
The gene defective in Huntington's disease encodes a protein, huntingtin, with unknown
function. Antisera generated against three separate regions of huntingtin identified a single …
function. Antisera generated against three separate regions of huntingtin identified a single …
Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription
KB Kegel, AR Meloni, Y Yi, YJ Kim, E Doyle… - Journal of Biological …, 2002 - ASBMB
Huntingtin is a protein of unknown function that contains a polyglutamine tract, which is
expanded in patients with Huntington's disease (HD). We investigated the localization and a …
expanded in patients with Huntington's disease (HD). We investigated the localization and a …
Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture
JK Cooper, G Schilling, MF Peters… - Human molecular …, 1998 - academic.oup.com
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an
expanding CAG repeat coding for polyglutamine in the huntingtin protein. Recent data have …
expanding CAG repeat coding for polyglutamine in the huntingtin protein. Recent data have …