Despite being involved in a number of functions, such as nociception and locomotion, spinal
lamina X remains one of the least studied central nervous system regions. Here, we show …

The spinal gray matter region around the central canal, lamina X, is critically involved in
somatosensory processing and visceral nociception. Although several classes of primary …

Presynaptic inhibition of primary afferent terminals is a powerful mechanism for controlling
sensory information flow into the spinal cord. Lamina I is the major spinal nociceptive …

The role of spinal dorsal horn propriospinal connections in nociceptive processing is not yet
established. Recently described, rostrocaudally oriented axon collaterals of lamina I …

Spinal lamina II (substantia gelatinosa) neurons play an important role in processing of
nociceptive information from primary afferent nerves. Anatomical studies suggest that …

Spinal lamina I and the lateral spinal nucleus (LSN) receive and integrate nociceptive
primary afferent inputs to project through diverse ascending pathways. The pattern of the …

The most superficial layer of the spinal dorsal horn, lamina I, is a key element of the
nociceptive processing system. It contains different types of projection neurons (PNs) and …

The dorsal horn of the spinal cord (laminae I-VI) processes diverse modalities of nociceptive
and nonnociceptive sensory information. Antenna-type neurons with cell bodies located in …

The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and
as such, offers a very powerful target for regulation of nociceptive transmission by both local …

Lamina I of the spinal cord plays a key role in sensory transmission between afferent activity
and the CNS. Studies have shown lamina I neurones to have distinct response properties …