Introducing optimal experimental design in predictive modeling: A motivating example

KJ Versyck, K Bernaerts, AH Geeraerd… - International Journal of …, 1999 - Elsevier
Predictive microbiology emerges more and more as a rational quantitative framework for
predicting and understanding microbial evolution in food products. During the mathematical …

On the design of optimal dynamic experiments for parameter estimation of a Ratkowsky-type growth kinetics at suboptimal temperatures

K Bernaerts, KJ Versyck, JF Van Impe - International journal of food …, 2000 - Elsevier
It is generally known that accurate model building, ie, proper model structure selection and
reliable parameter estimation, constitutes an essential matter in the field of predictive …

Computing optimal dynamic experiments for model calibration in predictive microbiology

E BALSA‐CANTO, AA Alonso… - Journal of Food Process …, 2008 - Wiley Online Library
The potential of mathematical models describing the microbial behavior during food
processing and storage largely depends on their predictive capabilities and, in this concern …

The impact of experiment design on the parameter estimation of cardinal parameter models in predictive microbiology

E Van Derlinden, L Mertens, JF Van Impe - Food Control, 2013 - Elsevier
In predictive food microbiology, cardinal parameter models are often applied to describe the
effect of temperature, pH and/or water activity on the microbial growth rate. To identify the …

Comparing experimental design schemes in predictive food microbiology: Optimal parameter estimation of secondary models

L Mertens, E Van Derlinden, JF Van Impe - Journal of Food Engineering, 2012 - Elsevier
In predictive food microbiology, full factorial designs are still more the rule than the
exception, despite the huge experimental workload and cost related to this method. In this …

Food engineering and predictive microbiology: on the necessity to combine biological and physical kinetics

P Mafart - International Journal of Food Microbiology, 2005 - Elsevier
Predictive microbiology is mainly applied in the area of risk assessment, but unusually
regarded as a tool for the optimisation of processes, which needs the implementation of food …

Experimental design, data processing and model fitting in predictive microbiology

M Van Boekel, MH Zwietering - Modelling microorganisms in food, 2007 - books.google.com
Models are simplifications of the real world and they are tools to handle complex matters in
research, in product and process design, in risk analysis and in management. Furthermore …

Dynamic mathematical model to predict microbial growth and inactivation during food processing

JF Van Impe, BM Nicolaï, T Martens… - Applied and …, 1992 - Am Soc Microbiol
Many sigmoidal functions to describe a bacterial growth curve as an explicit function of time
have been reported in the literature. Furthermore, several expressions have been proposed …

Optimal characterization of thermal microbial inactivation simulating non-isothermal processes

A Garre, G González-Tejedor, JL Peñalver-Soto… - Food Research …, 2018 - Elsevier
In this paper, optimal experimental design is applied for the characterization of the microbial
inactivation of Listeria monocytogenes under non-isothermal conditions, modelled by the …

Data-driven approaches to the modelling of bioprocesses

K Bernaerts, JF Van Impe - Transactions of the Institute of …, 2004 - journals.sagepub.com
Bioprocess modelling presents a challenging subject, which requires a meticulous
modelling strategy. During the modelling process, experimental data form a key ingredient …